Relationship Between Adipose Tissue Distribution and Arterial Stiffness in HFpEF

Heart Failure With Preserved Ejection Fraction Clinical Trial

Official title:

Relationship Between Adipose Tissue Distribution and Arterial Stiffness in Heart Failure With Preserved Ejection Fraction(HFpEF)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05095688
• Other study ID #: 2020-09-19
• Status: Recruiting
• Start date: September 21, 2020
• Est. completion date: December 31, 2022

Study information

• Verified date: October 2021
• Source: Chongqing Medical University
• Contact: Dongying Zhang, doctor
• Phone: +8613608398395
• Email: zdy.chris[@]qq.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.

Description:

Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: December 31, 2022
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

1. Adult aged >=18years old;

2. Diagnosed with HFpEF.

Diagnostic criteria including:

1. left ventricular ejection fraction =50%;

2. with the symptoms and/or signs of heart failure;

3. BNP=35 pg/mL and/or NTproBNP=125 pg/mL;

4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction

Exclusion Criteria:

1. LVEF less than 45% at any time;

2. Severe liver failure; 3/Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;

4.Primary pulmonary hypertension; 5.Severe valvular disease of the left heart; 6.Chronically bedridden or incapacitated; 7.Age <18 years old.

Related Conditions & MeSH terms

• Arterial Stiffness
• Heart Failure
• Heart Failure With Preserved Ejection Fraction
• Lipid Disorder
• Lipid Metabolism Disorders

Locations

Country	Name	City	State
China	The First Affiliated Hospital of Chongqing Medical University	Chongqing

Sponsors (1)

Lead Sponsor	Collaborator
Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Arterial stiffness	The baPWV(cm/s) of HFpEF patients	1 day after admission
Primary	adipose tissue distribution	The visceral fat area(cm^2) in HFpEF patients	1 day after admission