Metabolic Syndrome, Protection Against Clinical Trial
Official title:
The Relationship Between Workplace Environment and Metabolic Syndrome in Different Industries
The prevalence of MetS and its components among industrial workers and its risk factors correlates among them and compare them with those in employees from a nonindustrial setting, and explore the influence of different industries on hematological parameters especially WBCs derangement
Status | Not yet recruiting |
Enrollment | 156 |
Est. completion date | October 30, 2022 |
Est. primary completion date | June 30, 2022 |
Accepts healthy volunteers | |
Gender | Male |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Active workers more than 1 year in selected plants with matched controls from employee of Assiut University. Exclusion Criteria: 1. Workers who had been working for less than 1 year in their petrochemical plants 2. Workers with self-reported and/or diagnosed carcinomas, hematological diseases, and/or immune diseases. 3. Workers taking any medicine in the preceding 2 weeks affecting lipid profile & blood picture. 4. Workers unwilling to provide biological samples or doing so in insufficient volume. 5. Workers diagnosed MetS and its components before joing the petrochemical industry. 6. Workers with morbid obesity BMI > 40 |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
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Hidaka T, Hayakawa T, Kakamu T, Kumagai T, Hiruta Y, Hata J, Tsuji M, Fukushima T. Prevalence of Metabolic Syndrome and Its Components among Japanese Workers by Clustered Business Category. PLoS One. 2016 Apr 15;11(4):e0153368. doi: 10.1371/journal.pone.0153368. eCollection 2016. — View Citation
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Mini GK, Sarma PS, Thankappan KR. Overweight, the major determinant of metabolic syndrome among industrial workers in Kerala, India: Results of a cross-sectional study. Diabetes Metab Syndr. 2019 Sep - Oct;13(5):3025-3030. doi: 10.1016/j.dsx.2018.07.009. Epub 2018 Jul 17. — View Citation
Sajid Jabbar A, Ali ET. Impact of Petroleum Exposure on Some Hematological Indices, Interleukin-6, and Inflammatory Markers of Workers at Petroleum Stations in Basra City. J Environ Public Health. 2020 Aug 4;2020:7693891. doi: 10.1155/2020/7693891. eCollection 2020. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Metabolic Syndrome no. among each group | MetS was defined according to International Diabetes Federation criteria as: central obesity (defined as waist circumference 90 cm for men and 80 cm for women, plus any two of the following four factors: Raised TG level (150 mg/dl or on treatment for lipid abnormality), reduced HDL cholesterol (¼90 cm for men and >¼80 cm for women and any two of the following four factors: triglycerides >¼150 mg/ dl, reduced HDL cholesterol (<40 mg/dl in men and <50 mg/dl in women or on treatment for lipid abnormality), raised blood pressure (systolic blood pressure 130 mm Hg or diastolic blood pressure 85 mm Hg or on treatment for hypertension),raised fasting plasma glucose (FPG) (FPG100 mg/dl or on treatment for diabetes). | up to 12 weeks From date of randomization until the date of first documented progression | |
Primary | Nutritional health behavior | nutritional health behavior was obtained using the subscale of Health-Promoting Lifestyle Profile II. Nutritional health behavior included the following nine items: "choose a low-fat diet"; "limit the use of sugars"; "eat servings of bread, cereal, and rice"; "eat servings of fruit"; "eat servings of vegetables"; "eat servings of meat, poultry, fish, dried beans, eggs and nuts"; "eat servings of milk, yogurt or cheese"; "read labels to identify nutrients"; and "eat breakfast." The number of daily servings for each food group was set according to the dietary guidelines, Participants were asked to rate nine items on a four-point Likert scale, ranging from 1 (never) to 4 (routinely). A higher mean score indicated a greater level of participation in nutritional health behavior. | up to 12 weeks From date of randomization until the date of first documented progression | |
Secondary | blood sample for Complete blood picture | 5 ml of blood to measure WBCs derangement | up to 12 weeks From date of randomization until the date of first documented progression |
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