Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation

Weaning From Mechanical Ventilation Clinical Trial

Official title:

Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04779463
• Other study ID #: Parasternal Intercostals US
• Status: Recruiting
• Start date: June 1, 2020
• Est. completion date: April 1, 2021

Study information

• Verified date: February 2021
• Source: Menoufia University
• Contact: Wesameldin A Soltan, M.D.
• Phone: 0020101012215
• Email: wesamsultan1[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Assessment of the the parasternal intercostal muscles thickness by the ultrasonography as a weaning predictor of the mechanically ventilated patients

Description:

impact of parasternal muscle thickness on the weaning process of the mechanically ventilated patients in ICU

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: April 1, 2021
• Est. primary completion date: March 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

Any patient invasively mechanically ventilated at least 24 hours on a pressure support mode who is clinically stable and ready to undergo a spontaneous breathing trial.

All patients will be:

• Alert.

• Afebrile.

• Adequate cough with absence of excessive tracheobronchial secretion.

• Fraction of inspired oxygen (FIO2) of <50%.

• PEEP =8 cmH2O.

• PaO2/FiO2 > 150.

• pH =7.35 and =7.45.

• Respiratory rate (RR) =35 breaths/min.

• Hemodynamically stable in the absence of vasopressors.

• Stable metabolic and endocrinal status.

• Euglycemic state.

• Adequate mentation (no sedation or stable neurologic patient).

Exclusion Criteria:

Diaphragmatic paralysis (detected by ultrasonography).Patients&Methods. 6

• Pregnant women.

• Age: >= 18 years.

• Surgical dressings over measurement point which would preclude ultrasound exam.

• Underweight patients (Body mass index <18.5 kg/m2).

• Morbidly obese patient (Body mass index = 40 kg/m2).

• Primary neuro-muscular diseases.

• Central coditions with depressed central respiratory drive (encephalitis, and brainstem haemorrhage/ischaemia).

• Repiratory conditions with reduced pulmonary compliance (interstitial lung disease, pulmonary hemorrhage, and diffuse pulmonary infiltrates) or reduced chest wall compliance (kyphoscoliosis).

• Cardiac conditions with high risk of weaning induced pulmonary edema (congestive heart failure, cyanotic heart diease, pulmonary hypertension, and ischemic heart diease).

• Addict patients.

• Patients with psychiatric disease.

Related Conditions & MeSH terms

• Parasternal Intercostal Muscle Thickness
• Weaning From Mechanical Ventilation

Intervention

Diagnostic Test:
• Parasternal intercostal muscles thickness ultrasound indicies
Parasternal intercostal muscles thickness ultrasound indicies includes: Parasternal Intercostals Thickness Fraction. Parasternal Intercostals Thickness at the End of Inspiration. Parasternal Intercostals thickness at the End of Expiration.

Locations

Country	Name	City	State
Egypt	Faculty of Medicine - Menoufia University	Shibin Al Kawm	Menoufia

Sponsors (1)

Lead Sponsor	Collaborator
Wesameldin Abelrahman Soltan

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials	The primary outcome is to assess the change of the parasternal intercostal muscles thickness at end of expiration and end of inspiration to verify the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials.	Before the start spontaneous breathing trial