Weaning From Mechanical Ventilation Clinical Trial
Official title:
Postextubation Non-invasive Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Weaning Failure: a Physiologic Randomized Crossover Study
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure. Currently, non-invasive ventilation (NIV) is recommended to prevent weaning failure in high-risk patients. On the other hand, high-flow nasal cannula (HFNC), which is a novel system capable of administering gas mixtures (air and oxygen) with a flow of up to 60 liters/min, has been used to prevent weaning failure in this kind of patients. The use of NIV and HFNC after extubation has been evaluated in some clinical studies. However, the evidence is controversial, and the information regarding the physiological effects that each therapy induces in recently extubated patients at high risk of weaning failure is lacking. The goal of this proposal is to compare the acute physiological effects of postextubation NIV versus HFNC in critically ill patients at high risk of weaning failure on relevant mechanisms related to weaning failure: Work of breathing, lung function, ventilation distribution, systemic hemodynamics. This will be a randomized crossover study that will include critically ill mechanically ventilated patients, who fulfill criteria indicating they may be ready for weaning from mechanical ventilation, and in whom a spontaneous breathing trial (SBT) is planned to determine if they should be extubated. After checking eligibility and obtaining informed consent, patients will be monitored with an esophageal catheter (esophageal/gastric pressures to determine work of breathing, and electric activity of diaphragm to determine neuromechanical coupling), and a noninvasive ventilation monitor (electric impedance tomography to assess global and regional ventilation). Work of breathing, lung function, and systemic hemodynamics will be assessed during the SBT. Inclusion in the study will be confirmed only if they pass the SBT and are extubated. During the first 2 hours after extubation, patients will undergo one hour of NIV and one hour of HFNC, with the crossover sequence being randomized previously at the time of inclusion and with assessments repeated at the end of each treatment period.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04792788 -
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
|
N/A | |
| Completed |
NCT02855619 -
Comparison of the Impact of Three Programs of Inspiratory Muscles.
|
N/A | |
| Completed |
NCT03962322 -
Diaphragmatic Tissue Doppler During Weaning From Mechanical Ventilation
|
N/A | |
| Completed |
NCT03140267 -
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
|
N/A | |
| Recruiting |
NCT03018483 -
Mechanical Ventilation- Weaning and Thoracic Impedance Tomography
|
N/A | |
| Completed |
NCT01666054 -
Comparison of Weaning on Pressure Support vs. Proportional Assist Ventilation: A Pilot Study
|
N/A | |
| Recruiting |
NCT04779463 -
Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation
|
||
| Recruiting |
NCT02361021 -
Lung Aeration During WEANing From Mechanical Ventilation Determined by Electrical Impedance Tomography and Lung Ultrasound
|
N/A | |
| Completed |
NCT04227639 -
T-piece Versus Pressure-support for the Spontaneous Breathing Trial
|
N/A | |
| Not yet recruiting |
NCT04224246 -
Impact of Gamma-OH on Sleep in ICU Patients
|
Phase 2 | |
| Recruiting |
NCT05000034 -
Nurses-driven, Capnography-guided Protocol Weaning From the Mechanical Ventilation at Bedside: A Feasibility Study
|
N/A | |
| Completed |
NCT01967108 -
Post Extubation Chest Physiotherapy in ICU
|
N/A |