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Genetic of Response to Acute Saline Load Test in Hypertension (Naload) — Naload  

Genetic Predisposition to Disease Clinical Trial

Official title:
Role of Genetic Determinants in the Response to Acute Saline Load Testing in Patients With Essential Hypertension (Naload)

Clinical Trial Summary

NHP referred to our outpatient clinic will be enrolled (150 newly recruited) in acute saline test for phenotype characterisation of PNat relationship(7). For each patient we will collect urine and blood samples for standard clinical biochemistry, including electrolytes, creatinine, EO, aldosterone, plasma renin activity, urinary uromodulin (ELISA), urinary and serum uric acid and blood samples for genetic test.

Clinical Trial Description

Acute salt load test: after the equilibration period and achievement of a steady state, a constant-rate i.v. infusion of 2 L of 0.9% NaCl was carried out in 2 hours. BP (mean of 3 measurements taken 3 minutes apart) was measured every 30 minutes during the 2 hours of loading and 3 times at 3-min intervals at the end of the infusion. These last 3 BP values were averaged and used in the analysis. The results of these tests will be added to an already collected database of salt load test collected in the previous studies (already published) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04625569
Study type Observational
Source Ospedale San Raffaele
Contact Chiara Lanzani, doctor
Phone 0206433891
Email lanzani.chiara@hsr.it
Status Recruiting
Phase
Start date July 8, 2019
Completion date September 30, 2025
View Details
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