Metastatic Castration-resistant Prostate Cancer Clinical Trial
Official title:
177Lu-PSMA-I＆T PSMA Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer
The purpose of this study is to determine the safety and efficacy of 177 Lu -labeled PSMA ligand(PSMA-I＆T) in the treatment of mCRPC in Asianethics.
Prostate specific membrane antigen(PSMA) targeted therapy brings new hope to the patients
with metastatic castration-resistant prostate cancer (mCRPC). Here, we reported the safety
and efficacy of 177 Lu -labeled PSMA ligand(PSMA-I＆T) in the treatment of mCRPC in
Asianethics.
Prostate cancer is the most common cancer diagnosed in older men with recent data .PSMA is a
type II transmembrane glycoprotein，overexpressed up to 100 to 1000 times higher than normal
prostate cells in prostate cancer cells and is correlated with higher-grade cancers,
metastatic disease and hormone refractory disease. Lutetium-177 (177Lu)-PSMA (LuPSMA) is a
novel and highly targeted systemic RLT for progressive mCRPC. Upon binding of LuPSMA to the
cell membrane, endocytosis is triggered, concentrating the tumouricidal effects of the
radioisotope activity internally within malignant cells.
This is a single-institution, single-arm phase 2 clinical trial. Patients will receive PRLT
Treatment. The follow-up period was followed up to assess safety and effectiveness.
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