Non-Alcoholic Fatty Liver Disease Clinical Trial
Official title:
Understanding the Role of Macrophage-mediated Inflammation in White Adipose Tissue and Liver Fibrosis
Verified date | December 2023 |
Source | Imperial College London |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Non-alcoholic fatty liver disease (NAFLD) is present in one third of the population and due to its potential to cause irreversible liver damage and liver cancer, it is a significant health burden. There is a strong link between obesity and NALFD. As fat accumulates, the body is unable to process it, leading to unhealthy fat metabolism. Currently, other than lifestyle measures and better control of Type 2 Diabetes Mellitus (T2DM) with medication, there is no drug that can prevent or reverse the liver damage. Furthermore, there is no easy way to identify which person will go on to develop the liver damage. Mounting evidence suggests that inflammation in the fat has a key role in driving liver damage, particularly by the immune cell called the macrophage. However, detailed mechanisms are lacking. Therefore, the aim of this proposal is to study obese patients with NAFLD to better understand the link between unhealthy fat metabolism and liver damage, focusing on identifying macrophage-derived drug targets which can potentially reverse the liver disease. Samples of fat and liver from patients who are having bariatric surgery at Imperial College Healthcare NHS Trust will be analysed to identify and target the inflammatory markers of unhealthy fat and NAFLD using genetic profiling techniques.
Status | Completed |
Enrollment | 48 |
Est. completion date | September 5, 2023 |
Est. primary completion date | September 5, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Bariatric and Upper Gastrointestinal (UGI) surgery patients classified as obese or morbidly obese (BMI >30) - Patients who attend UGI cancer services with a BMI <25 Exclusion Criteria: Participants with: - alcohol consumption more than 10g of ethanol per day - viral Hepatitis infection - HIV - Autoimmune condition - genetic liver disease - other metabolic causes of liver disease - abnormal clotting - immunosuppressive medication - drugs that are known to precipitate hepatic steatosis. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Imperial College NHS Trust | London |
Lead Sponsor | Collaborator |
---|---|
Imperial College London |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Macrophage ligand-fibroblast receptor | Macrophage ligand-fibroblast receptors that are assessed by single cell-RNA-sequencing | 3 years |
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