Uncontrolled Donation After Circulatory Determination of Death (uDCDD)

Uncontrolled Donation After Circulatory Determination of Death Clinical Trial

— uDCDD  

Official title:

Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03935230
• Other study ID #: 2016-1416
• Status: Completed
• Start date: May 2016
• Est. completion date: August 2016

Study information

• Verified date: June 2016
• Source: Université de Sherbrooke
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.

Description:

While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1111
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.

Exclusion Criteria:

• Patients with a status of no resuscitation

• Pediatric patients (<18 years old)

• Adults >65 years old

Related Conditions & MeSH terms

• Death
• Uncontrolled Donation After Circulatory Determination of Death

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Université de Sherbrooke

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Potential contribution of a uDCDD program on the number of additional donors.	Defined as (must meet all criteria): Age =70 years old; Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury); Absence of surgical cause of cardiac arrest; No sign of IV drug abuse; No history of malignancies	1 year
Secondary	Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.	Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.	1 year
Secondary	Number of tissus donors	Number of tissus donors	1 year
Secondary	Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.	Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.	1 year
Secondary	Areas of future research.	Areas of future research.	1 year