Athletes With Isolated Non-ischemic LGE With no Underlying Labelled Cardiomyopathy Clinical Trial
Official title:
Effect of Intense Sport Practice in Athletes With Non-ischemic Scar
The prognostic relevance of isolated non-ischemic LGE (i.e. with no underlying "labelled"
cardiomyopathy) is unclear, and current guidelines to not state on the clearance of athlete
with this type of findings as regards to competitive or intense sport practice.
The principal objective of the study is to evaluate during a five-years follow up, the
clinical outcome of athletes with this kind of findings. The secondary objective is the
determination of prognostic factors. The management and follow-up of the athletes will be let
at the appraisal of each center.
The presence of a scar, assessed by late gadolinium enhancement (LGE) on cardiac resonance
imaging (CMR), is associated with a poor prognosis in patients with ischemic heart disease or
cardiomyopathy. But the prognostic relevance of isolated non-ischemic LGE (i.e. with no
underlying "labelled" cardiomyopathy) is unclear, and current guidelines do not state on the
clearance of athlete with this type of findings as regards to competitive or intense sport
practice.
The objective of the study is to evaluate the clinical outcome of athletes with isolated
non-ischemic LGE with no underlying "labelled" cardiomyopathy during a five-years follow-up.
The secondary objective is the determination of prognostic factors based on the baseline
inclusion data: indication of CMR (i.e. symptoms, abnormal ECG, presence and morphology of
arrhythmias, abnormal echocardiography); localization and amount of LGE, left and right
ventricular geometry and function, characteristics of sport practice (amount, type,
competition).
The management of the athletes will be let at the appraisal of each centre, as regards to the
initial assessment, the follow-up and the medical clearance for competitive sports
participation. Nevertheless, due to the absence of consensus, we propose that the patient
should at least undergo clinical examination, ECG, echocardiography, cardiopulmonary exercise
test (CPET) and holter ECG each year. A CMR should be performed at one and five years.
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