Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss Clinical Trial
Official title:
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
1. Establish a multi-platform detection system for neutrophil extracellular traps in blood
and tissues, and evaluate the detection performance;
2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood
and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal
control group;
3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood
and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal
control group;
4. After treatment of antiphospholipid antibody-induced mouse abortion model with
metformin,the effect of metformin on embryo loss rate and viable embryo body weight was
observed.
| Status | Recruiting |
| Enrollment | 100 |
| Est. completion date | June 30, 2019 |
| Est. primary completion date | June 30, 2019 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Female |
| Age group | 25 Years to 41 Years |
| Eligibility |
Inclusion Criteria: - Clinical diagnosis of Recurrent spontaneous abortion - Clinical diagnosis of Antiphospholipid syndrome Exclusion Criteria: - Other autoimmune diseases - Hematopoietic system diseases - Cardiovascular system diseases - Gastrointestinal system diseases - Urinary system diseases - Nervous system or mental diseases - Have taken other drugs recently |
| Country | Name | City | State |
|---|---|---|---|
| China | Shanghai First Maternity and Infant Hospital | Shanghai |
| Lead Sponsor | Collaborator |
|---|---|
| Shanghai First Maternity and Infant Hospital |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Other | C3 level | Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. | through study completion, an average of 8 months | |
| Primary | NETs level | Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. | through study completion, an average of 8 months | |
| Secondary | complete blood count (CBC) | CBC is a blood panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood, such as the cell count for each blood cell type and the concentrations of hemoglobin. | through study completion, an average of 8 months |