Heart Failure With Reduced Ejection Fraction Clinical Trial
Official title:
The Impact of Ivabradine Administration on Clinical Outcome and Biomarkers of Decompensated Heart Failure
The aim of the work is to Evaluate the efficacy, quality of life and safety of early addition of ivabradine to B-blocker in reduced EF heart failure patients after acute decompensation compared to the standard treatment.
this study is a Prospective randomized open label study will be conducted on Egyptian patient
with heart failure with reduced ejection fraction(rEF HF). Each of the eligible patients will
be randomized to one of these groups, early administration of Ivabradine and B-blocker group
or control group which follows American Heart Association treatment guidelines of rEF HF.
The objectives include the following:
1. Physical examination (heart rate, blood pressure, dyspnea and orthopnea symptoms)
2. NYHA class
3. Pro-NT-BNP serum level, ST2 serum level
4. Echocardiography (left ventricular ejection fraction)
5. Score of Minnesota Living with Heart Failure Questionnaire these objectives will be
measured baseline, 2 weeks and after 3 months
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