Chronic Rhinosinusitis (Diagnosis) Clinical Trial
Official title:
Serum Cytokine Profiles of Severe Asthma
Verified date | July 2019 |
Source | TC Erciyes University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or chronic rhinosinusitis and/or nasal polyposis status.
Status | Completed |
Enrollment | 95 |
Est. completion date | June 28, 2019 |
Est. primary completion date | February 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria (for disease groups): 1. Patients diagnosed with severe asthma and followed-up at least 6 months at our clinic 2. Asthma that can only be complete or partly controlled with Global Initiative for Asthma (GINA) 4-5 treatment 3. Asthmatics that are eligible for the defined phenotypes 4. At least one perennial allergen sensitivity for the atopic groups Inclusion Criteria (for control group): 1. Non-asthmatics (without clinical and pulmonary function test evidence) 2. Non-atopics (proved by skin prick tests) 3. Serum eosinophil count <300/cells Exclusion Criteria (for disease groups): 1. <18 year-old 2. Smoking history within the last 1 year prior to the study 3. Asthmatics with inadequate inhaler technique and/or adherence problems 4. Comorbidities: malignancy history, connective tissue disorders, rheumatological disorders, hyperthyroidism, coronary heart diseases, diabetes mellitus, active hepatic diseases, akut kidney injury, any autoimmune diseases 5. Organ transplantation history 6. Pregnancy 7. Other pulmonary problems: chronic obstructive pulmonary disease (COPD), bronchiectasis, interstitial lung diseases, pulmonary thromboemboli 8. During stable period investigation 1. Asthma control test <20 2. Upper respiratory tract infections within 1 month before admission 3. Exacerbation and/or systemic steroid use within 1 month before admission 9. Atopic patients that only have seasonal allergen sensitivity Inclusion Criteria (for control group): 1. <18 year-old 2. Smoking history within the last 1 year prior to the study 3. Asthmatics with inadequate inhaler technique and/or adherence problems 4. Comorbidities: malignancy history, connective tissue disorders, rheumatological disorders, hyperthyroidism, coronary heart diseases, diabetes mellitus, active hepatic diseases, akut kidney injury, any autoimmune diseases 5. Organ transplantation history 6. Pregnancy 7. Other pulmonary problems: COPD, bronchiectasis, interstitial lung diseases, pulmonary thromboemboli 8. Without consent |
Country | Name | City | State |
---|---|---|---|
Turkey | Erciyes University School of Medicine Division of Allergy | Kayseri |
Lead Sponsor | Collaborator |
---|---|
TC Erciyes University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum cytokine levels | Measurement of stable state and exacerbation state levels of serum cytokines (IL-4, IL-5, IL10, IL-13, IL-17, IL-25, IL-33, TSLP, periostin) | 10 months | |
Secondary | Nasal brush sample PCR | Detecting pharyngeal pathogens with PCR taken during exacerbated state | 10 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05895929 -
The Role of IL5 in Epithelial Cell Integrity
|
Early Phase 1 | |
Completed |
NCT03673956 -
Topical Antibiotics in Chronic Rhinosinusitis
|
Phase 1/Phase 2 | |
Recruiting |
NCT03970655 -
Functional Endoscopic Sinus Surgery Study
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT04514120 -
Alsaleh-Javer Endoscopic Sinus Score (AJESS) System
|
N/A | |
Recruiting |
NCT03963648 -
NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP
|
N/A | |
Recruiting |
NCT05009758 -
Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps
|
N/A | |
Active, not recruiting |
NCT05553951 -
Adherence in Global Airways
|
N/A | |
Completed |
NCT05035654 -
LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)
|
Phase 2 | |
Withdrawn |
NCT03369574 -
Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab
|
||
Recruiting |
NCT05400616 -
Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
|
N/A | |
Recruiting |
NCT04628442 -
Tissue Immune Interaction in Nasal Polyposis
|
||
Completed |
NCT04041609 -
LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study)
|
Phase 2 | |
Completed |
NCT04048070 -
The Effect of Enhanced Recovery After Surgery in Endoscopic Sinus Surgery
|
N/A | |
Recruiting |
NCT03439865 -
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
|
Early Phase 1 | |
Recruiting |
NCT05857228 -
Viral and Epigenetic Influences in CRSwNP
|
||
Completed |
NCT03122795 -
Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
|
N/A | |
Recruiting |
NCT05295459 -
Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)
|
Phase 3 | |
Completed |
NCT04858802 -
A Clinical Evaluation of PROPEL® Contour Sinus Implant
|
N/A | |
Completed |
NCT04572516 -
Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis
|
Phase 3 | |
Completed |
NCT04595461 -
Effect of Patient Education Videos on Perioperative Anxiety in Patients Undergoing Endoscopic Sinus Surgery
|
N/A |