Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction Clinical Trial
Official title:
Interference Indicators of Growth, Nutritional Status and Comorbid Malformations of Newborns With Down Syndrome (DS)
Objective To access predictive values of the auxological parameters and indexes for risk of
comorbid malformations in newborns with Down syndrome (DS)
Study design In this cohort retrospective study, 141 newborns with proven trisomy 21 born at
the Department of Gynecology and Obstetrics of the University of Split Hospital (1990 to
2015) were included. The data were obtained from the medical histories of mothers, infants
and the delivery protocol.
The objective was to access predictive values of the auxological parameters and indexes for
risk of comorbid malformations in newborns with Down syndrome (DS)
Conclusion Higher CI were found in hyportrophic (SGA) newborns with DS and indicated their
intrauterine growth restriction with brain sparing and increased further risk of severe
psychomotor retardation. The SGA newborns have lower parameters and indexes of nutritive
status and significantly differed from eutrophic and hypertrophic newborns. These SGA
newborns with DS have increased developmental risks and that requires further diagnostic
attention.
Use of anthropometric charts developed specifically for children with DS have a better
expression of real growth restriction (small for gestation age/SGA, 9.9%) than the
application of the percentile curve for typical children (SGA, 24.1%). These differences were
also noted in the evaluation of other anthropometric measures. Cephalization index (CI)
proved to be the only predictor from the considered auxological parameters and indexes with
minimal predictive value in the prediction of heart defects type ASD II and VSD.
The presence of comorbid disorders in newborns with DS did not have a significant predictive
role on growth indicators and nutritive status of the newborn, but we noted a strong
association between preterm births and white matter injury (WMI).
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