Heart Failure With Preserved Ejection Fraction Clinical Trial
Official title:
Exploration of Dyspnea at Non-high BNP
Patients with unexplained stress dyspnea ( ≥ stage 2 NYHA), no significant underlying lung
disease, with an ejection fraction > 50%, normal resting filling pressures, NTproBNP < 220
pg/ml in < 75 years, and < 450 pg/ml in ≥ 75 years will be studied with stress
echocardiography and cardiometabolic stress test (VO2). These patients may have abnormal
adaptation during exercise, suggesting that chronic symptoms may be related to a heart
failure with preserved ejection fraction (HFPEF). More accurate and earlier diagnosis of
HFPEF using stress echocardiography and VO2 may better manage stress dyspnea in patients and
prevent progression of HFPEF.
A clinical assessment will be offered to people with unexplained stress dyspnea. The
procedures and products used in this study are usually used as part of HFpEF's diagnostic
strategy. During this assessment, carried out on an outpatient basis, an anamnesis
collection, a cardiovascular clinical examination, an evaluation of dyspnea by the NYHA
functional class and by 2 questionnaires, an electrocardiogram will be carried out, a
6-minute walk test, a biological blood test, a trans thoracic rest and stress cardiac
ultrasound, respiratory functional tests (with diffusion capacity of lung for carbon monoxide
(DLCO) and blood gas), and a metabolic stress test. A follow-up at 1 and 2 years is planned
(visit, sampling and resting echocardiography).
n/a
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