Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Calprotectin I in Serum as a Diagnostic Marker of Pneumonia in Patients Hospitalised With Acute COPD Exacerbation
Verified date | September 2018 |
Source | St. Olavs Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Patients diagnosed with pneumonia in addition to an AECOPD experience more severe clinical and laboratory disease manifestations, increase in-hospital morbidity and worse outcome. Clinicians have sought for new biomarkers that together with clinical assessments can improve the diagnostic accuracy of pneumonia in patients with AECOPD.The aim of the present study is to compare the accuracy of calprotectin with procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC).
Status | Completed |
Enrollment | 113 |
Est. completion date | September 14, 2018 |
Est. primary completion date | September 14, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - clinically confirmed acute exacerbation of chronic obstructive pulmonary disorder (AECOPD) - COPD diagnosis previously confirmed by spirometry according to the GOLD criteria. Exclusion Criteria: - known malignant disease - bronchiectasis - chronic bacterial colonisation of the airways - treatment with an immunosuppressive drug or long-term treatment with antibiotics. - not examined with a chest X-ray at admission |
Country | Name | City | State |
---|---|---|---|
Norway | Department of Thoracic and Occupational Medicine | Trondheim | Trøndelag |
Lead Sponsor | Collaborator |
---|---|
St. Olavs Hospital | Norwegian University of Science and Technology |
Norway,
Titova E, Aune MW, Fonn K, Henriksen AH, Åsberg A. Neutrophil CD64 Expression as a Diagnostic Marker in Patients Hospitalized with Exacerbations of COPD: A Prospective Observational Study. Lung. 2015 Oct;193(5):717-24. doi: 10.1007/s00408-015-9762-2. Epub 2015 Jul 15. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Calprotectin concentration in serum | ELISA-kit (MRP8/14 ELISA) | Change in serum concentration from baseline to 48 hours |
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