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Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

Premature Ventricular Contraction Clinical Trial

Official title:
Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

Clinical Trial Summary

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Clinical Trial Description

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03447002
Study type Observational
Source TC Erciyes University
Contact
Status Completed
Phase
Start date February 15, 2018
Completion date September 30, 2019
View Details
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