Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

Premature Ventricular Contraction Clinical Trial

Official title:

Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03447002
• Other study ID #: ErciyesU
• Status: Completed
• Start date: February 15, 2018
• Est. completion date: September 30, 2019

Study information

• Verified date: November 2019
• Source: TC Erciyes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Description:

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 30, 2019
• Est. primary completion date: September 30, 2019
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• PVC's rate is more than % 5 in 24 hours rhythm recording

Exclusion Criteria:

• ischemic heart disease

• hyperthyroidism

• patients with low ejection fraction

Related Conditions & MeSH terms

• Premature Birth
• Premature Ventricular Contraction
• Ventricular Premature Complexes

Intervention

Diagnostic Test:
• 24 hours urine levels metanephrine and normetanephrine
24 hours rhythm recording and 24 hours urine measurement

Locations

Country	Name	City	State
Turkey	Erciyes university Yilmaz- mehmet öztaskin heart hospital	Kayseri

Sponsors (1)

Lead Sponsor	Collaborator
TC Erciyes University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Bradfield JS, Homsi M, Shivkumar K, Miller JM. Coupling interval variability differentiates ventricular ectopic complexes arising in the aortic sinus of valsalva and great cardiac vein from other sources: mechanistic and arrhythmic risk implications. J Am Coll Cardiol. 2014 May 27;63(20):2151-2158. doi: 10.1016/j.jacc.2014.02.551. Epub 2014 Mar 19. — View Citation

Im SI, Park KM, Park SJ, Kim JS, On YK. New electrocardiographic criteria for predicting successful ablation of premature ventricular contractions from the right coronary cusp. Int J Cardiol. 2016 Dec 1;224:199-205. doi: 10.1016/j.ijcard.2016.09.029. Epub 2016 Sep 16. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	metanephrine and normetanephrine levels	metanephrine and normetanephrine levels asociated premature ventricular complex frequents	about 10 months