Epidemiology of Resistant Microbial Strains Among Different Groups of People (Healthy, Infected and Exposed to Animals)

Methicillin Resistant Staphylococcus Aureus (MRSA) Clinical Trial

— ABRESIST  

Official title:

Transfer Routes of Antibiotic Resistance

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03343119
• Other study ID #: SLOTI12038T
• Status: Active, not recruiting
• Start date: March 27, 2012
• Est. completion date: August 2019

Study information

• Verified date: October 2018
• Source: University of Tartu
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study investigates carriage rate and risk factors for acquiring multiresistant bacteria (ESBL producing E.coli and K.pneumoniae, carbapenem-resistant and multidrug resistant P.aeruginosa, MRSA and VRE) in hospitalised patients and healthy volunteers.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 708
• Est. completion date: August 2019
• Est. primary completion date: January 30, 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

I group Hospitalised patients Inclusion Criteria

• MDR bacteria (listed above) isolated from clinical specimen

• hospitalisation to the Tartu University Hospital or North Estonia Medical Centre or West Tallinn Central Hospital or East-Tallinn Central Hospital or The Hospital of Reconstructive Surgery

II group Healthy volunteers Inclusion Criteria

• age >6 months

• have not received any antibacterial treatment in previous 3 months

• have not been hospitalised in previous 3 months

III group Dog owners Inclusion Criteria

• age >6 months

• have not received any antibacterial treatment in previous 3 months

• have not been hospitalised in previous 3 months

• owning a dog

IV group veterinarians Inclusion Criteria

• have not received any antibacterial treatment in previous 3 months

• have not been hospitaliZed in previous 3 months

• working as a veterinarian

V group pig farmers Inclusion Criteria

• have not received any antibacterial treatment in previous 3 months

• have not been hospitalized in previous 3 months

• occupation as a pig farmer

Related Conditions & MeSH terms

• Carbapenem Resistant P.Aeruginosa
• ESBL Producing E.Coli
• ESBL Producing K.Pneumoniae
• Methicillin Resistant Staphylococcus Aureus (MRSA)
• Multidrug Resistant P.Aeruginosa
• Pneumonia
• Staphylococcal Infections
• Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of Tartu	Estonian University of Life Sciences

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Colonization rate with multiresistant (MDR) bacteria in hospitalized patients	To evaluate the impact of hospitalization for carriage and infection rate with MDR bacteria	March 2012 - March 2014
Primary	Colonization rate with multiresistant (MDR) bacteria in healthy humans	To evaluate the impact of animal exposure for carriage rate with MDR bacteria	March 2012 - March 2014