Coughing Responses at Tracheal Extubation Clinical Trial
Official title:
Comparison of the Effects of Oxycodone Versus Fentanyl on Airway Reflex to Tracheal Extubation and Postoperative Pain During Recovery of Anesthesia After Laparoscopic Cholecystectomy
This study was performed to compare the effects of oxycodone and fentanyl on airway and hemodynamic responses and postoperative pain during recovery period in patients undergoing laparoscopic cholecystectomy.
This study was approved by the committee of Institutional Review Board of the Yeungnam
University Hospital, Daegu, Republic of Korea. 90 patients were enrolled in this study and
written informed consent was obtained from all patients. We included patients with ASA
physical status classification I or II, and aged 18-65 years scheduled for elective
laparoscopic cholecystectomy.
Patients were assigned to one of three groups by computer-generated randomization, fentanyl
group (group F, N=30), oxydodone group (group O, N=30), or control group (group C, N=30). 10
minutes before completion of surgery, patients received 2 mL mixture of fentanyl 1 ㎍/kg or
oxycodone 0.08 mg/kg with isotonic saline or isotonic saline 2 mL intravenously in accordance
with allocated study groups by an anesthesiologist who was blinded to group treatment.
Airway reflex responses including coughing, breath holding, bucking, and laryngospasm were
recorded at point of awareness, extubation, and 3 min after tracheal extubation. Hemodynamic
responses were recorded at the completion of surgery (T1), at the point of awareness (T2), at
the point of extubation (T3), and 3 min after tracheal extubation (T4). Coughing severity was
assessed using a 5-point scale. In the recovery room, hemodynamic responses were evaluated
every 5 min for 30 min. The postoperative pain intensity was assessed 5 and 30 min in the
postanesthetic care unit (PACU) using numerical rating scale (NRS) ranging from 0 (no pain)
to 10 (worst possible pain).
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