Upper Respiratory Tract Infections, Asthma, Exhaled Breath Clinical Trial
Official title:
Using Breath Metabolites to Determine Specific Virus Infection in Asthmatic Patients
| Verified date | August 2021 |
| Source | University of California, Davis |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
Respiratory virus infections cause a majority of asthma exacerbations in the fall to spring months. Current diagnostic platforms for respiratory viruses have limitations including cost, availability, and invasiveness. The use of noninvasive breath collection to analyze breath metabolites may be used to differentiate virus-infected asthmatics from other causes of acute asthma exacerbations.
| Status | Completed |
| Enrollment | 19 |
| Est. completion date | September 1, 2020 |
| Est. primary completion date | March 10, 2020 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 12 Years and older |
| Eligibility | Inclusion Criteria: - Asthma, Age =12, Symptoms/signs of an early asthma exacerbation, Ability to provide exhaled breath condensate (EBC) x15 min, Body mass index (BMI) =18 Exclusion Criteria: - Chronic lung diseases other than asthma (e.g., chronic obstructive pulmonary disease [COPD], lung cancer, fibrotic lung disease, etc.), Smoking in the past 7 days, Eating or non-clear liquids <4 hrs prior to EBC collection, Pregnancy |
| Country | Name | City | State |
|---|---|---|---|
| United States | University of California Davis Medical Ceneter | Sacramento | California |
| Lead Sponsor | Collaborator |
|---|---|
| University of California, Davis | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Breath metabolite differences between groups | Metabolites from breath will be identified and quantified using gas chromatography-mass spectrometry; these will be compared between groups. Specific breath metabolites include isoprostane, linear and branched alkanes (C6-C9), alcohols, and thiol-containing moieties. However, we will also measure metabolites in an un-targeted manner. | 36 months |