Aneurysmal Subarachnoid Hemorrhage, Familial Clinical Trial
Official title:
Non Invasive Measurements of Intracranial Pressure After Aneurysmal Subarachnoid Hemorrhage
In patients at risk of increased intracranial pressure (ICP), ICP measurements require
invasive transducers, usually with insertion of a catheter into the cranium, or through a
spinal tap. These invasive modalities involve risks and pain and they can be done only in
specialized care units, with a high associated cost.
A novel method for detecting changes in ICP has developed recently. The auditory hair cells
emit sounds and electric signals in response to sound, which can be easily detected and
measured non-invasively with the help of a microphone probe placed in the external ear canal
or regular electrodes. Indeed, the cochlear aqueduct connects the cerebrospinal fluid (CSF)
spaces to the inner ear in such a way that ICP and inner-ear fluid pressure equalize within
seconds.
The evaluation of intracranial hypertension by increased ICP (invasive) is not
systematically used after aneurysmal subarachnoid hemorrhage. It is then detected by using
routine clinical signs of hydrocephalus or another disorder of cerebrospinal liquid flow, in
combination with a standard imaging method (TDM).
The measurement of noninvasive ICP could allow earlier detection of hydrocephalus or another
disorder of cerebrospinal liquid flow, and evaluate whether the increase in ICP precedes
patient clinical worsening and / or imaging.
In patients at risk of increased intracranial pressure (ICP), ICP measurements require
invasive transducers, usually with insertion of a catheter into the cranium, or through a
spinal tap. These invasive modalities involve risks and pain and they can be done only in
specialized care units, with a high associated cost.
A novel method for detecting changes in ICP has developed recently. The auditory hair cells
emit sounds and electric signals in response to sound, which can be easily detected and
measured non-invasively with the help of a microphone probe placed in the external ear canal
or regular electrodes. Indeed, the cochlear aqueduct connects the cerebrospinal fluid (CSF)
spaces to the inner ear in such a way that ICP and inner-ear fluid pressure equalize within
seconds.
The evaluation of intracranial hypertension by increased ICP (invasive) is not
systematically used after aneurysmal subarachnoid hemorrhage. It is then detected by using
routine clinical signs of hydrocephalus or another disorder of cerebrospinal liquid flow, in
combination with a standard imaging method (TDM).
The measurement of noninvasive ICP could allow earlier detection of hydrocephalus or another
disorder of cerebrospinal liquid flow, and evaluate whether the increase in ICP precedes
patient clinical worsening and / or imaging.
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