B-cell Acute Lymphoblastic Leukemia Clinical Trial
Official title:
The Safety and Efficacy of CART-19 Cells in Relapse and Refractory Patients With CD19+ B-cell Acute Lymphoblastic Leukemia.
This is a study for patients who have been previously treated for B-ALL. The purpose of this study is to determine the safety and feasibility of CART-19 cells to the patients with relapsed and refractory CD19+ B-ALL.
Subjects will be staged and the suitability of their T cells for CART-19 manufacturing will
be determined at entry phase,. Subjects will be collected large numbers of peripheral blood
mononuclear cells (PBMC) for CART-19 manufacturing. The T cells will be purified from the
PBMC, transduced with CART-19 lentiviral vector, expanded in vitro and then administered to
subjects.
Subjects will have blood tests to assess safety and efficacy, and persistence of the CART-19
cells at regular intervals through four weeks after their last infusion of the study.
Following the 6 months of intensive follow-up, subjects will be evaluated quarterly for two
years with a physical examination, blood tests, bone marrow aspirate, minimal residual
disease (MRD) and persistence of CART-19. Following this evaluation, subjects will be
evaluated health problems every year for an additional thirteen years.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03671460 -
CD19 CAR-T Cells for Patients With Relapse and Refractory CD19+ B-ALL.
|
Phase 1 | |
| Recruiting |
NCT06056752 -
QH103 Cell Injection for the Treatment of Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
|
Phase 1 | |
| Recruiting |
NCT05016947 -
Venetoclax Plus Inotuzumab for B-ALL
|
Phase 1 | |
| Suspended |
NCT01974479 -
Pilot Study of Redirected Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
|
Phase 1 | |
| Completed |
NCT00289562 -
Forodesine Hydrochloride (BCX-1777) for B-Cell Acute Lymphoblastic Leukemia
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06034275 -
Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies
|
Phase 1 | |
| Recruiting |
NCT04191941 -
Treatment of Hematological Malignancy With Novel CAR-T Cells.
|
Early Phase 1 | |
| Recruiting |
NCT05333302 -
Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma
|
Phase 1 | |
| Recruiting |
NCT04129099 -
A Study of GC022F CAR-T Cell Immunotherapy for Relapsed or Refractory B- ALL
|
Early Phase 1 | |
| Recruiting |
NCT05651191 -
To Evaluate the Safety and Efficacy of Human CD19 Targeted DASH CAR-T Cells Injection for Subjects With R/R B-ALL
|
Early Phase 1 | |
| Recruiting |
NCT04150497 -
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
|
Phase 1 | |
| Withdrawn |
NCT05571540 -
Anti-CD19 Universal CAR-T Cells for r/r CD19+ B-ALL
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03281551 -
Efficacy and Safety of PZ01 Treatment in Patients With r/r CD19+ B-cell Acute Lymphoblastic Leukemia/B Cell Lymphoma
|
Phase 1 | |
| Recruiting |
NCT05379647 -
Natural Killer (NK) Cell Therapy for B-Cell Malignancies
|
Phase 1 | |
| Withdrawn |
NCT04156659 -
Study of Tisagenlecleucel in Chinese Pediatric and Young Adult Subjects With Relapsed or Refractory B-cell ALL
|
Phase 2 | |
| Recruiting |
NCT04094311 -
Study of Out of Specification for Tisagenlecleucel
|
Phase 3 | |
| Completed |
NCT01207388 -
Confirmatory Phase II Study of Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL)
|
Phase 2 | |
| Active, not recruiting |
NCT03467256 -
CD19 T-CAR for Treatment of Children and Young Adults With r/r B-ALL
|
Phase 1/Phase 2 | |
| Terminated |
NCT04844086 -
RPM CD19-mbIL15-CAR-T Cells in Patient With Advanced Lymphoid Malignancies
|
Phase 1 | |
| Recruiting |
NCT05648019 -
CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory B-Lineage Leukaemia / Lymphoma - A Feasibility Protocol
|
Phase 2 |