Systemic Inflammatory Response Syndrome Clinical Trial
Official title:
Myeloid-Derived Supressor Cells in Uncomplicated vs Complicated Patients After Cardiac Surgery
Pro- and anti-inflammatory response during the formation of the critical state develops at
the same time. Because of its balanced or unbalanced systemic inflammation can be either
aborted or able to lead to multiple organ failure. With regard to sepsis, systemic
inflammatory response characteristics are well understood, is not achieved in respect of the
"sterile" inflammation.
Extracorporeal circulation is a clinical model of systemic inflammatory response due to
non-physiological activation of tissue factor in the extracorporeal perfusion, the use of
non-pulsatile circulation mode, intentional / unintentional hypothermia, bacterial
translocation from the gastrointestinal tract and perfusion deficit.
We have proved that the monocytes demonstrate suppressor function, which can be a predictor
of complications from cardiac surgery patients.
The most important component of the formation of multiple organ failure (MOF) in critically
ill patients is immunosuppression.
During the study of experimental and clinical tumor growth process scientists has provided a
new population of immature myeloid cells (myeloid suppressor cells or suppressor cells of
myeloid origin, MDSC). Most of the works have been devoted to the role of MDSC in the
development of tumors, where it has been clearly shown that this cell population has an
undoubted effect of immune suppression. However, recent studies show that the role of MDSC is
not limited to cancer process, but extends to chronic or acute inflammation.
The aim of this study is to determine the role of MDSC in the development of immune
suppression and complications after heart surgery carried out under cardiopulmonary bypass.
The use of MEC systems can be useful to prevent the MDSC activation after cardiac surgery.
The procedures to modulate the cytokines concentration can be useful to prevent the MDSC
activation after cardiac surgery.
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