Acute Lymphoblastic Leukemia (ALL) Clinical Trial
Official title:
Ma-Spore ALL 2010 Study
The overall objective of this study is to continue to improve the cure rate of childhood acute lymphoblastic leukemia (ALL) in Singapore and Malaysia in the context of a multi-centre cooperative trial using a risk-stratified therapy based primarily on early response to therapy utilizing a simplified minimal residual disease (MRD-lite) platform.
The study was designed on the premise that a risk classification strategy combining clinical
and genetic presenting features with molecular assessment of MRD should reduce both
treatment-related toxicities and relapse risk.
The patient will be assigned to one of the 3 risk groups depending on his/her response to
the treatment and special laboratory tests. There are no experimental drugs in this study.
All the drugs used are standard established treatment for childhood ALL for the last 30
years. The difference in treatment is by changes in the frequency and dose of the
chemotherapy drugs.
The overall study treatment lasts for about 2 years.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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