Purpura, Thrombocytopenic, Idiopathic Clinical Trial
— PTIREGOfficial title:
The Role of Regulatory B Cells in the Chronic Immune Thrombocytopenia
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.
Status | Completed |
Enrollment | 36 |
Est. completion date | September 2015 |
Est. primary completion date | September 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Purpura, Thrombocytopenic, Idiopathic, chronic phase (>12 months) - no treatment or thrombopoietin receptor agonists Exclusion Criteria: - < 18 years - Purpura, Thrombocytopenic, Idiopathic, acute phase - pregnancy - others causes of thrombopenia |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | CHRU de Brest | Brest |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Brest |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Regulatory B cells functionality | inhibition of T cells proliferation with co-culture B and T cells | 1 week | No |
Secondary | Cytometry immunophenotyping of B and T cells | characterization of B and T cells by flow cytometry | 1 week | No |
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