State Key Laboratory of Respiratory Disease Clinical Trial
The purpose of this study is to assess the Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease patients.
In total, 50 patients with interstitial lung disease (ILD) are going to recruited.The
patients are studied at the afternoon in a semirecumbent position. After the application of
topical anaesthesia (2% xylocaine), the patient will be asked to swallow two balloon-tipped
catheters and the multi-pair esophageal electrode catheter through the nose into the their
right position.
At the first period, the stable signals of unassisted spontaneous breathing (about 10min)
were chosen to be recorded. The Esophageal and gastric balloon－catheters are used to detect
the intra-thoracic and abdominal pressure.The diaphragm electromyogram (EMGdi) will be
recorded from a multipair esophageal electrode.The baseline data of the respiratory muscle
activity will be detected by these catheters and electrode.p0.1 (the negative airway
pressure generated during the first 100 ms of an occluded inspiration) will be also
meassured.
After the first period, the nonvolitional tests on respiratory muscle function and strength
(twitch mouth and transdiaphragmatic pressure during bilateral magnetic phrenic nerve
stimulation (TwPmo and TwPdi) will be done.
After the second period,the patients will be ask to perform different maneuvers, including
maximal inspiration against a closed valve ,maximal inspiration to total lung capacity
(TLC),maximalexpiration at the total lung capacity (TLC) against a closed valve and maximal
sniff from functional residual capacity(FRC).Each maneuver will repeated more than three
times with an interval of 30 s or more. Inspiratory capacity(IC),global maximal inspiratory
pressure (PImax), maximal sniff nasal pressure (SnPna) and maximalexpiratory pressure will
be meassured with the balloon－catheters.The maximal value of the diaphragm electromyogram
(EMGdi) will be recorded during these maneuvers.
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Observational Model: Cohort
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02817035 -
Study of Neural Inspiratory Time and Expiratory Delay in Patient and Health During Spontaneous Breathing and Ventilation
|
N/A |