Lower Respiratory Tract Infections Clinical Trial
Official title:
Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections-A Prospective Multicenter Clinical Trial (BALFinder Study)
Comparison of microbiological yield from Bronchoalveolar Lavage Fluid (BALF) for the two
common-used volume bronchoalveolar lavages(60ml and 120ml)in patients with different types
of lower respiratory tract infection.
Assessment of the safety of two common-used volume bronchoalveolar lavages(60ml and 120ml),
including the incidence of hospital-acquired pneumonia within 14 days after bronchoscopy,
and other bronchoalveolar lavage related adverse events.
The morbidity and mortality of lower respiratory tract infection gradually increased in
recent years, but the etiological diagnosis rate is still low. Quickly identifying the
pathogenic bacteria and the corresponding antimicrobial therapy treatment is particularly
important. Fibrotic bronchoscopy combined with bronchoalveolar lavage (BAL) has become a
routine diagnostic tool for pulmonary infections in immunocompromised patients.
The correct operation of bronchoalveolar lavage and normalization of bronchoalveolar lavage
fluid is a prerequisite for the exact results of the pathogen of BALF.
American Thoracic Society recommended amount of 100-300ml of saline solution was instilled
into the distal bronchial tree in the diagnosis of interstitial lung diseases. But there is
no standard of lavage fluid volume in the etiological diagnosis of lower respiratory tract
infections, ranging from 60ml to 250ml ever reported in literature.
Less lavage volume would be more safer in patients with lower respiratory tract infections.
The investigators hypothesize that microbiological yield would be no significant difference
in patients with low volume （60ml) compared with large volume (120ml).
The purpose of this study is to explore a more effective and safer way of bronchoalveolar
lavage in lower respiratory tract infection patients, and determine the pathogenic
distribution among them.
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