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Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation — M'RHICO  

Acute Respiratory Distress Syndrome (ARDS) Clinical Trial

Official title:
Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation

Clinical Trial Summary

This study aims to compare 2 alveolar recruitment maneuvers (ARM) in patients with cerebral injuries and acute respiratory distress syndrome (ARDS) in term of efficacy and tolerance.

Clinical Trial Description

Two ARM are compared in this study: - The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cm H2O with decrease of tidal volume (Vt) if necessary. - The continuous positive airway pressure, or Continuous Positive Airway Pressure (CPAP) with application of a positive pressure of 40 cm H2O for 40 seconds without tidal volume. Patients are randomized to receive in cross-over 2 ARM: CPAP and Extended Sigh (eSigh). The following data: oxygen tissue partial pressure (PtiO2), respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02574169
Study type Interventional
Source University Hospital, Toulouse
Contact Ségolène MROZEK, MD
Phone 05 61 77 21 67
Email mrozek.s@chu-toulouse.fr
Status Recruiting
Phase N/A
Start date September 1, 2016
Completion date December 2025
View Details
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