Clinical Trials Logo

Clinical Trial Summary

The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is impacted by the neuro-hormone Oxytocin. Specifically, the investigators plan to evaluate the influence of Oxytocin administration on affective processing in non-trauma exposed and trauma-exposed adults (both with and without posttraumatic stress disorder, PTSD).


Clinical Trial Description

The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is impacted by the neuro-hormone Oxytocin. Specifically, the investigators plan to evaluate the influence of Oxytocin administration on affective processing in non-trauma exposed and trauma-exposed adults (both with and without posttraumatic stress disorder, PTSD). The investigators expect oxytocin (compared to placebo) to positively influence affect processing in healthy subjects, as well as among those diagnosed with PTSD. Given current literature, the investigators expect oxytocin to elevate the processing\perception of positive-related stimuli, and reduce the salience of aversive or un-pleasant cues. The investigators expect oxytocin to impact participants' brain function as measured with functional magnetic resonance imaging (fMRI) while visually processing social and affect-related stimuli, rendering brain function and affective processing to be "more typical" or "adaptive" compared to placebo. Oxytocin's effect on human repertoire is not necessarily direct, but can interact with the individual's socioemotional characteristics, early life environment, and psychiatric symptoms. Therefore, the investigators will incorporate measures that capture the various dimensions that likely shape the effect of oxytocin. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02546570
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Phase 2
Start date August 2015
Completion date August 2016

See also
  Status Clinical Trial Phase
Completed NCT01443182 - Treatment of Posttraumatic Stress Disorder (PTSD) in Adult Survivors of Early Chronic Interpersonal Trauma N/A
Completed NCT01507948 - Brain Imaging of Psychotherapy for Posttraumatic Stress Disorder (PTSD) N/A
Completed NCT02911285 - NAC for Treating Comorbid PTSD and SUD Phase 2
Recruiting NCT02234076 - A Study on the Efficacy of Virtual Reality Exposure Therapy (VRET) for Survivors of Childhood Sexual Abuse and War Related Trauma N/A
Completed NCT01729026 - A Study of Dog Adoption in Veterans With Posttraumatic Stress Disorder (PTSD) Early Phase 1
Completed NCT01406834 - Treatment for the Mental Health Impact of Killing in War N/A
Completed NCT01446146 - Increasing Engagement in PTSD Treatment Through Patient Education and Patient Choice N/A
Completed NCT01464892 - Imagery Rescripting in the Treatment of Post Traumatic Stress Disorder (PTSD) Following Early Chronic Interpersonal Trauma N/A
Active, not recruiting NCT03283163 - Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD N/A
Completed NCT02442843 - Non Invasive Brain Stimulation for PTSD Early Phase 1
Completed NCT01888653 - Attention-Bias Modification Treatment for PTSD N/A
Completed NCT01474057 - DElivery of Self Training and Education for Stressful Situations-Primary Care Version Phase 2
Completed NCT00672776 - Effects of Paxil CR on Neural Circuits in Posttraumatic Stress Disorder (PTSD) Phase 4
Completed NCT03641924 - Cognition and Psychotherapy in PTSD
Completed NCT02397889 - Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD) Phase 2/Phase 3
Completed NCT02322047 - Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders Phase 2
Completed NCT00320138 - Acupuncture for the Treatment of Posttraumatic Stress Among Military Personnel Phase 1
Recruiting NCT03833453 - Effectiveness of PTSD-treatment Compared to Integrated PTSD-PD-treatment in Adult Patients With Comorbid PTSD and BPD N/A
Completed NCT03833531 - Effectiveness of PTSD-treatment Compared to Integrated PTSD-PD-treatment in Adult Patients With Comorbid PTSD and CPD N/A
Completed NCT03529435 - Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD N/A