Alcohol and Other Drug Use Disorders Clinical Trial
Official title:
Oklahoma Family Health Patterns: A Study Across Generations
Verified date | January 2017 |
Source | The University of Texas Health Science Center at San Antonio |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The researchers are studying factors that may increase the risk for alcohol and drug use in
individuals who do not have any problems with these substances. This study will be looking
at health behaviors in young adults compared to their family's health behaviors and
lifestyle.
The investigators plan to study genetic differences in people with and without a family
history of alcoholism. The researchers hope to learn how a family history of alcoholism,
early life adversity and different genotypes shape personal characteristics associated with
a risk for alcoholism.
Status | Completed |
Enrollment | 139 |
Est. completion date | September 2016 |
Est. primary completion date | September 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - Male or female sex - Age 18-29 years - Normal health based on routine history and physical - Willingness to provide a DNA sample - No required CNS-acting medications, history of neurological impairment, or diabetes mellitus - Normal color vision - Normal intelligence based on Shipley Institute of Living verbal scale score = 20 (John & Rattan, 1992) - Negative urine drug screen at entry and each lab visit (icup, Alcopro, Knoxville, TN) and alcohol breath test (AlcoMate CA2000, KHN Solutions, San Francisco) - Volunteers must have been raised by at least one biological parent and have knowledge of and contact with same Exclusion Criteria: - Pregnancy - Any failure to meet inclusion criteria - Rearing by other than a biological parent - Suspected maternal alcoholism during pregnancy with proband, determined by interview with subject or parent - AUDIT score > 12 - Inability of parent to provide credible report of family alcohol use patterns for two generations - Current Axis I disorder by DIS-IV, excepting past depression or abuse of alcohol or drugs (all > 60 days) - Axis II disorder in Clusters A or C by SCID II. AXIS II symptoms in Cluster B are not exclusionary because antisocial and behavioral undercontrol variables related to substance use disorders overlap with Cluster B symptoms. Past abuse of alcohol and other substances is not exclusionary in order to allow a wide range of intake while still avoiding severe consequences of intake history. |
Country | Name | City | State |
---|---|---|---|
United States | University of Texas Health Science Center at San Antonio | San Antonio | Texas |
Lead Sponsor | Collaborator |
---|---|
The University of Texas Health Science Center at San Antonio | National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assess behavioral risk factors in young adults with and without family histories of alcohol and other drug use disorders | Participants will be assessed on 3 laboratory visits lasting a few hours each. All 3 visits will typically be competed within 3-4 weeks. | ||
Primary | Collect physiological measures of stress reactivity in young adults with and without family histories of alcohol and other drug use disorders | Participants will be assessed on 3 laboratory visits lasting a few hours each. All 3 visits will typically be competed within 3-4 weeks. | ||
Primary | Collect DNA in young adults with and without family histories of alcohol and other drug use disorders | DNA will be collected once during one of the participants' 3 laboratory visits lasting a few hours each. All 3 visits will typically be competed within 3-4 weeks. . | ||
Primary | Maintain DNA repository for DNA analyses | The DNA repository will be maintained over the 5 year study duration. |