PTSD - Post Traumatic Stress Disorder Clinical Trial
Official title:
Low-Frequency Versus High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Posttraumatic Stress Disorder
This is a randomized placebo/sham controlled, double-blind study investigating the efficacy of high- and low-frequency rTMS applied to the right DLPFC at either 1 Hz, 10 Hz, or sham rTMS as compared to an OASIS treatment as usual group for the treatment of PTSD symptoms.
The study will be carried out within the Overcoming Adversity and Stress Injury Support
(OASIS) program administered by Naval Medical Center San Diego (NMSD). OASIS is a residential
treatment program developed for active duty service members diagnosed with combat related
PTSD. OASIS is a 9 week program in which cohorts of 10 patients undergo a variety of
therapeutic activities with a focus on cognitive processing therapy (CPT) of combat trauma
conducted in both group and individual formats.
Subjects who qualify will be assigned by block randomization to one of four arms:
1. 1 Hz rTMS of the right dorsolateral prefrontal cortex
2. 10 Hz rTMS of the right dorsolateral prefrontal cortex
3. Sham rTMS of the right dorsolateral prefrontal cortex
4. OASIS treatment as usual
Treatment will be administered in 10 daily sessions, conducted on weekdays, for 2 consecutive
weeks. .
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