Anterior Cutaneous Nerve Entrapment Syndrome (ACNES) Clinical Trial
Official title:
Nociceptive Processing in Acute Cutaneous Nerve Entrapment Syndrome: a Quantitative Sensory Testing Analysis.
Rationale: Chronic abdominal pain is a frequently occurring condition. Although hardly ever
considered, the abdominal wall is the primary cause in 10-30% of cases. Most often it is
caused by entrapment of an intercostal nerve in the anterior rectus sheath, the Anterior
Cutaneous Nerve Entrapment Syndrome (ACNES). Treatment consists of local anaesthetic
injections combined with methyl-prednisolon. When ineffective, a neurectomy at the site of
penetration out of the ventral rectus sheet should be considered. This neurectomy however is
effective in 73% of cases, leaving some 25% of patients in pain. Whether these refractory
ACNES patients suffer from underlying pathologic pain disorders is subject to investigation,
by using quantitative sensory testing (QST).
Objective: To investigate nociceptive processing and possible underlying pathological pain
processing mechanisms in ACNES patients.
Study design: An observational case-control study.
Study population: Patients treated for ACNES (n = 50) compared to healthy controls from an
existing database.
Measurements: Quantitative sensory testing (QST) of nociception, performed after treatment
of ACNES for both successfully treated and refractory patients in comparison to healthy
controls. Visual Analogue Scores (VAS) measured before, during and after testing procedures.
Pain Anxiety Symptom Scale (PASS) and Pain Catastrophizing Scale (PCS) questionnaires.
Main study parameters: Pressure pain and electrical pain thresholds as investigated by QST.
Secondary study parameters are VAS-scores and results of PASS and PCS questionnaires.
n/a
Observational Model: Case Control, Time Perspective: Prospective