Sleep Disorders, Circadian Rhythm Clinical Trial
Official title:
Cross Sectional Study of Sleep-wake and Melatonin Patterns in Patients Treated for Craniopharyngiomas Compared to Matched Controls
The hypothalamus is a part of the brain containing a number of nuclei with a variety of
functions. It is central in the regulation of hormone secretion, sleep, and circadian
functions. The suprachiasmatic nucleus of the hypothalamus is a key component in controlling
circadian rhythms and generates the rhythm of melatonin secretion from the pineal gland and
cortisol secretion. Both melatonin and cortisol are involved in the regulation of circadian
rhythms and sleep.
Craniopharyngiomas are a type of brain tumors that usually affect the hypothalamus
indirectly. In general, they are locally aggressive invading crucial structures e.g. the
hypothalamus, the pituitary, and the optic nerve. Compared to healthy controls,
craniopharyngioma patients have previously been reported with impaired quality of life,
increased self-reported general and physical fatigue, increased daytime sleepiness, and
increased prevalence of severe sleepiness
Damage to the hypothalamus by local tumour or its treatment might involve the
suprachiasmatic nucleus and thereby melatonin secretion leading to disturbed circadian
function causing clinical manifestations in terms of daytime sleepiness and fatigue.
The investigators aimed to assess the influence of craniopharyngiomas or their treatment on
melatonin secretion, and the association with sleep pattern, sleep quality, fatigue, and
sleepiness.
15 patients with craniopharyngioma and 15 gender, age, and BMI matched healthy controls were
included. Salivary melatonin and cortisol were measured over a 24h-period. Sleep-wake
patterns were characterized by two weeks of actigraphy recordings and sleep diaries.
Sleepiness, fatigue, sleep quality, and general health were assessed by questionnaires.
The hypothalamus is a part of the brain containing a number of nuclei with a variety of
functions. It is central in the regulation of hormone secretion, sleep, and circadian
functions. The suprachiasmatic nucleus of the hypothalamus is a key component in controlling
circadian rhythms and generates the rhythm of melatonin secretion from the pineal gland and
cortisol secretion. Both melatonin and cortisol are involved in the regulation of circadian
rhythms and sleep.
Craniopharyngiomas are a type of brain tumors that usually affect the hypothalamus
indirectly. In general, they are locally aggressive invading crucial structures e.g. the
hypothalamus, the pituitary, and the optic nerve. Compared to healthy controls,
craniopharyngioma patients have previously been reported with impaired quality of life,
increased self-reported general and physical fatigue, increased daytime sleepiness, and
increased prevalence of severe sleepiness
Damage to the hypothalamus by local tumour or its treatment might involve the
suprachiasmatic nucleus and thereby melatonin secretion leading to disturbed circadian
function causing clinical manifestations in terms of daytime sleepiness and fatigue.
The investigators aimed to assess the influence of craniopharyngiomas or their treatment on
melatonin secretion, and the association with sleep pattern, sleep quality, fatigue, and
sleepiness.
15 patients with craniopharyngioma and 15 gender, age, and BMI matched healthy controls were
included. Salivary melatonin and cortisol were measured over a 24h-period. Sleep-wake
patterns were characterized by two weeks of actigraphy recordings and sleep diaries.
Sleepiness, fatigue, sleep quality, and general health were assessed by questionnaires.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05346588 -
THRIVE Feasibility Trial
|
Phase 3 | |
| Recruiting |
NCT05991453 -
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
|
N/A | |
| Withdrawn |
NCT05096130 -
Lifestyle Medicine Strategies for Combating Sleepiness and Fatigue in Professional Drivers
|
N/A | |
| Completed |
NCT01327040 -
Light Sensitization Study
|
N/A | |
| Completed |
NCT00593736 -
Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome
|
Phase 2 | |
| Recruiting |
NCT00387179 -
Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders
|
N/A | |
| Recruiting |
NCT04900675 -
Bright Light Intervention to Reduce Students' Stress
|
N/A | |
| Completed |
NCT00246051 -
Comprehensive Police Fatigue Management Program
|
N/A | |
| Recruiting |
NCT04690504 -
Validation of Circadian Biomarkers in Patients With Sleep Disorders
|
||
| Completed |
NCT03363529 -
ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards
|
N/A | |
| Recruiting |
NCT05701969 -
Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
|
Early Phase 1 | |
| Completed |
NCT00723580 -
Actigraphic Analysis of Treatment Response
|
N/A | |
| Completed |
NCT00207285 -
Sleep Disorders Management, Health and Safety in Police
|
N/A | |
| Not yet recruiting |
NCT06336525 -
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
|
||
| Recruiting |
NCT05618405 -
Changes in Circadian Rhythm After Anaesthesia in Children
|
||
| Completed |
NCT05684523 -
Feasibility Study on the Use of Redormin®500 on Day-time Cognition
|
Phase 4 | |
| Recruiting |
NCT05247125 -
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
|
Phase 4 | |
| Completed |
NCT04219566 -
Vestibular Nerve Stimulation to Improve Sleep
|
N/A | |
| Not yet recruiting |
NCT06181110 -
Sleep-Wake Patterns on Illness Trajectories and Treatment Response in MDD
|
N/A | |
| Not yet recruiting |
NCT06233422 -
Longitudinal Ecological Study on Sleep-Wake Patterns in MDD Using Actigraphy
|