End- Stage Renal Disease Patients Clinical Trial
Official title:
The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study (NSARF)
Hemodynamic instability occurs frequently during dialysis treatment and still remains as significant cause of patient mobility and mortality. Postoperative hemodynamic optimization has been proved to reduce morbidity in high-risk patients. Intracranial pressure increased can lead to further structural and functional impairment owing to its deleterious effect on the compromised microcirculation and metabolism. This study was to compare the intra-cerebral pressure (ICP) and hemodynamic parameters between the sustained low-efficiency dialysis (SLED) and continuous veno-venous hemofiltration (CVVH) in post- brain tramatic patients.
Patients and Methods This study was based on a clinical cohort study of the renal failure
patients in the database of the National Taiwan University Surgical ICU Acute Renal Failure
(NSARF) Study Group17-21, with the approval of the Institutional Review Board of the
National Taiwan University Hospital (201107015RC).
Study protocol
The inclusion criteria were end stage renal disease (ESRD) patients with increased ICP
status post ICP monitor insertion. We started the study after the hemodynamic stable and
acceptable ICP less than 20mmHg22. The ESRD patients with active brain hemorrhage, cardiac
arrhythmia during dialysis, residual urine output, with inotropic equivalent more than 15
were excluded.
All the patients were ventilated in supine position in controlled-volume mode after stable
from brain hemorrhage. During data collection, supportive therapies, ventilatory settings
and vasopressor therapy were kept unchanged. Patients were randomized to receive CVVH or
SLED and the next day on the other. The ICP monitor was equipped and the indwelling radial
artery catheter connected to the FloTrac/Vigileo hemodynamic monitoring system and for whom
the ultrafiltration rate was set around 1.0 kg/8hr to 1.5 kg/8hr according to fluid status.
Ultrafiltration rate and sodium concentration were fixed during each session.
Clinical assessment The biochemical parameters were measured using the Toshiba TBA-200FR
Clinical Chemistry Analyzer (Toshiba, Tochigi-Ken, Japan). When multiple daily measurements
were performed, the data obtained closest to 8:00 AM were analyzed 23. The baseline
hemodynamic was defined as average of two hours prior dialysis in each dialysis sessions.
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Observational Model: Case-Crossover, Time Perspective: Prospective