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Intracranial Hypertension clinical trials

View clinical trials related to Intracranial Hypertension.

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NCT ID: NCT03556085 Not yet recruiting - Clinical trials for Idiopathic Intracranial Hypertension

Venous Sinus Stenting With the River Stent in IIH

Start date: June 2018
Phase: N/A
Study type: Interventional

The objective of the study is to show that stenting the transverse-sigmoid sinus with the River stent is safe and has probable benefit to relieve clinical symptoms in subjects with idiopathic intracranial hypertension (IIH). The study will enroll 39 IIH subjects with moderate to severe visual field loss or severe headaches that have failed medical therapy. The primary safety endpoint is the rate of major adverse event at 12 months The primary probable benefit endpoint is a composite at 12 months of absence of significant sinus stenosis and clinically relevant improvement.

NCT ID: NCT03531723 Not yet recruiting - Hydrocephalus Clinical Trials

Brain Ultrasound in the Weaning of External Ventricular Leads

Start date: June 2018
Study type: Observational

External Ventricular Deviation (EDV) is a medical device that provides transient and controlled external drainage of cerebrospinal fluid (CSF). This device can also monitor intracranial pressure (ICP). SEV is an emergency measure indicated for acute hydrocephalus and / or intracranial hypertension (HTIC). Weaning from a DVE should be considered as soon as possible from the moment the patient's clinical condition allows it. There is no consensus on how to wean SEVs. The main objective of this study is to evaluate inter and intraobserver reproducibility of the measurement of the 3rd ventricle size by ultrasound in patients receiving a DVE withdrawal test.

NCT ID: NCT03529370 Not yet recruiting - Clinical trials for Intracranial Hypertension

Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Ressure (ICP)

Start date: June 1, 2018
Study type: Observational

In this study the invistigators chose to measure the optic nerve sheath diameter by sonography for diagnosis of elevated intracranial pressure (ICP) in comparison to brain computed tomograhy (CT) as the reference gold standard for detection of raised ICP since optic nerve songraphy is radiation-free , noninvasive, and has certain features which increase its convenience portability, easy application, low cost, repeatability on request, bedside application, short application time and applicability even in the presence of unstable vital signs.

NCT ID: NCT03501966 Not yet recruiting - Clinical trials for Idiopathic Intracranial Hypertension

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Start date: May 2018
Phase: Phase 3
Study type: Interventional

Randomized trial of adults (≥18 years old) with idiopathic intracranial hypertension and moderate to severe visual loss without substantial recent treatment who are randomly assigned to (1) medical therapy, (2) medical therapy plus ONSF, or (3) medical therapy plus VPS. The primary outcome is visual field mean deviation change at first of Month 6 (26 weeks) or time of treatment failure of the eligible eye(s), followed by a continuation study to assess time to treatment failure. The determination of eligible eye(s) is based on meeting the eligibility criteria at baseline.

NCT ID: NCT03418753 Not yet recruiting - Clinical trials for Intracranial Pressure Increase

Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure

Start date: March 2018
Phase: N/A
Study type: Observational

The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external ventriculostomy drain (EVD) or ventriculostomy catheter.

NCT ID: NCT03409237 Not yet recruiting - Clinical trials for Intracranial Hypertension

Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension

Start date: April 1, 2018
Phase: N/A
Study type: Observational

Osmotherapy consists in the therapeutic use of osmotically active substances with the aim of reducing the volume and therefore the intracranial pressure. It therefore represents an essential component in the clinical management of cerebral edema and intracranial hypertension, whether they are a consequence of head trauma, ischemic or hemorrhagic stroke, and neoplasm or neurosurgical procedures. The current study aims at evaluating in vivo the effects on haemostasis parameters of hypertonic saline solutions at different concentration, as compared to mannitol, in patients with neuroradiological signs (CT / MRI) of cerebral edema / non-traumatic intracranial hypertension.

NCT ID: NCT03373292 Not yet recruiting - Headache Clinical Trials

Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis

Start date: January 2018
Phase: Phase 1
Study type: Interventional

This is a prospective, randomized, single-center clinical study aiming to explore the safety and efficacy of venous stenting for patients with internal jugular vein stenosis (IJVS).

NCT ID: NCT03364634 Completed - Clinical trials for Traumatic Brain Injury

Intracranial Pressure After Decompressive Craniectomy

Start date: October 1, 2015
Phase: N/A
Study type: Observational

Observational study to investigate the natural course of intracranial pressure (ICP) after decompressive craniectomy (DC) using long-term telemetric ICP monitoring. Patients will have continuous ICP measurement performed during the admission to the neuro-intensive care unit (NICU) and after discharge weekly measurements sessions will be performed before and after cranioplasty.

NCT ID: NCT03354143 Recruiting - Hypertension Clinical Trials

Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)

Start date: April 10, 2018
Phase: Phase 2
Study type: Interventional

The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase brain amyloid beta protein accumulation and affect memory and thinking ability in older adults. However, whether lowering blood pressure reduces brain amyloid beta protein and improves brain function is inconclusive. The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces brain amyloid beta protein accumulation and improves brain structure and function.

NCT ID: NCT03344432 Recruiting - Clinical trials for Intraocular Pressure

Correlation Intraocular Pressure With Intracranial Pressure

Start date: June 10, 2015
Phase: N/A
Study type: Observational [Patient Registry]

Severe Trauma Brain Injury (TBIs) is a public health problem and monitoring of Intracranial Pressure (ICP) is a determinant key of it prognosis. Within the noninvasive methods to estimate the ICP, the measurement of intraocular pressure has been proposed because of its biological plausibility (proximity of the eye to the encephalic contend). Objective. Correlate intraocular pressure with ICP in children with TBIs and obtain their utility values.