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Intracranial Hypertension clinical trials

View clinical trials related to Intracranial Hypertension.

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NCT ID: NCT03641443 Recruiting - Clinical trials for Intracranial Pressure Increase


Start date: September 12, 2016
Phase: N/A
Study type: Interventional

Since decades, neurosurgeons and neurooncologists assumed that the mass effect of brain tumors with peritumoral edema or intratumoral hemorrhage might lead to increased ICP. Therefore, decisions on surgical procedures and medical treatments were made based on clinical and radiological findings suggesting increased ICP. But in fact, no measurement has ever confirmed increased ICP in brain tumor patients. From an ethical point of view, it is not justifiable to implant an intraparenchymal ICP probe within an invasive surgical procedure in a brain tumor patient unless the patient is comatose or present with rapid impairment of the level of consciousness. Therefore, with the new medical device for non-invasive ICP measurement presented in this study protocol, we will be able to measure absolute ICP values in patients with brain tumors.

NCT ID: NCT03640741 Completed - Laparoscopy Clinical Trials

Changes in Cerebral Oxygenation Studies During Laparoscopy Procedure

Start date: July 11, 2016
Study type: Observational

The motivation results from the fact, that an intra-abdominal pressure is correlated with cerebral perfusion, in a mechanism of reducing venous outflow. Moreover, elevated intra-abdominal pressure leads to increase in intracranial pressure and decrease of cerebral perfusion pressure. The main aim of the study was to investigate an influence of increase in intra-abdominal pressure on cerebral oxygenation measured with the use of non-invasive optical technique.

NCT ID: NCT03634176 Recruiting - Clinical trials for Intracranial Hypertension

Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies

Start date: February 1, 2017
Study type: Observational

Measurement of the diameter of the sheath of the optic nerve in patients hospitalized in intensive care, with increased intracranial pressure (> 20mmHg) as a substitute measure for diagnosis and follow-up before and after different non-invasive strategies. Five groups were created in which, through strategies already proven and non-invasive (mannitol, hypertonic solution 7.5% NaCl, dexamethasone, furosemide, reverse trendelenburg) to decrease the intracranial pressure, the optic nerve diameter measurement was performed and simultaneously the investigators monitored intracranial pressure through an intraventricular catheter continuously to determine if both correspond

NCT ID: NCT03609866 Not yet recruiting - Clinical trials for Intracranial Pressure Increase

Chest Physiotherapy Effects on Intracranial Pressure

Start date: November 30, 2018
Phase: N/A
Study type: Interventional

The investigators will study the effects of a chest physiotherapy technique (rapid abdominal thoracic compression) on the intracranial pressure of individuals with acute cerebral injury and with need of intubated mechanical ventilation

NCT ID: NCT03556085 Recruiting - Clinical trials for Idiopathic Intracranial Hypertension

Venous Sinus Stenting With the River Stent in IIH

Start date: August 24, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to show that stenting the transverse-sigmoid sinus with the River stent is safe and has probable benefit to relieve clinical symptoms in subjects with idiopathic intracranial hypertension (IIH). The study will enroll 39 IIH subjects with moderate to severe visual field loss or severe headaches that have failed medical therapy. The primary safety endpoint is the rate of major adverse event at 12 months The primary probable benefit endpoint is a composite at 12 months of absence of significant sinus stenosis and clinically relevant improvement.

NCT ID: NCT03531723 Recruiting - Hydrocephalus Clinical Trials

Brain Ultrasound in the Weaning of External Ventricular Leads

Start date: July 12, 2018
Study type: Observational

External Ventricular Deviation (EDV) is a medical device that provides transient and controlled external drainage of cerebrospinal fluid (CSF). This device can also monitor intracranial pressure (ICP). SEV is an emergency measure indicated for acute hydrocephalus and / or intracranial hypertension (HTIC). Weaning from a DVE should be considered as soon as possible from the moment the patient's clinical condition allows it. There is no consensus on how to wean SEVs. The main objective of this study is to evaluate inter and intraobserver reproducibility of the measurement of the 3rd ventricle size by ultrasound in patients receiving a DVE withdrawal test.

NCT ID: NCT03529370 Recruiting - Clinical trials for Intracranial Hypertension

Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Ressure (ICP)

Start date: September 1, 2018
Study type: Observational

In this study the invistigators chose to measure the optic nerve sheath diameter by sonography for diagnosis of elevated intracranial pressure (ICP) in comparison to brain computed tomograhy (CT) as the reference gold standard for detection of raised ICP since optic nerve songraphy is radiation-free , noninvasive, and has certain features which increase its convenience portability, easy application, low cost, repeatability on request, bedside application, short application time and applicability even in the presence of unstable vital signs.

NCT ID: NCT03501966 Not yet recruiting - Clinical trials for Idiopathic Intracranial Hypertension

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Start date: August 2018
Phase: Phase 3
Study type: Interventional

Randomized trial of adults (≥18 years old) with idiopathic intracranial hypertension and moderate to severe visual loss without substantial recent treatment who are randomly assigned to (1) medical therapy, (2) medical therapy plus ONSF, or (3) medical therapy plus VPS. The primary outcome is visual field mean deviation change at first of Month 6 (26 weeks) or time of treatment failure of the eligible eye(s), followed by a continuation study to assess time to treatment failure. The determination of eligible eye(s) is based on meeting the eligibility criteria at baseline.

NCT ID: NCT03418753 Recruiting - Clinical trials for Intracranial Pressure Increase

Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure

Start date: May 10, 2018
Study type: Observational

The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external ventriculostomy drain (EVD) or ventriculostomy catheter.

NCT ID: NCT03409237 Not yet recruiting - Clinical trials for Intracranial Hypertension

Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension

Start date: January 7, 2019
Study type: Observational

Osmotherapy consists in the therapeutic use of osmotically active substances with the aim of reducing the volume and therefore the intracranial pressure. It therefore represents an essential component in the clinical management of cerebral edema and intracranial hypertension, whether they are a consequence of head trauma, ischemic or hemorrhagic stroke, and neoplasm or neurosurgical procedures. The current study aims at evaluating in vivo the effects on haemostasis parameters of hypertonic saline solutions at different concentration, as compared to mannitol, in patients with neuroradiological signs (CT / MRI) of cerebral edema / non-traumatic intracranial hypertension.