Carriers of Carbapenem-resistant Klebsiella Pneumonia Clinical Trial
Official title:
SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS
There is an urgent need to control the current national outbreak of Carbapenem-resistent
Klebsiella pneumonia (CRKP). In Israel, the death rate among CRKP carriers is 3.5 times
higher than in Carbapenem-sensitive Klebsiella pneumonia carriers (44% vs. 12.5%,
respectively).
In the investigators' previous study: A Randomized, Double-Blind, Placebo-Controlled Trial
of Selective Digestive Decontamination (SDD) Using Oral Gentamicin and Oral Polymyxin E for
Eradication of CRKP Carriage (Infect Control Hosp Epidemiol. 2012;33:14-19) the
investigators have shown that the investigators' SDD regimen is effective for decolonization
patients colonized with CRKP.
The investigators' assumption is that a higher dose of polymyxin E together with gentamicin
(SDD drugs) for a prolonged period is needed to overcome the likelihood of a high rate of
drug inactivation in the gut, thereby reaching CRKP carriage eradication.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label