Chronic Liver Disease With Tuberclosis Clinical Trial
Official title:
Study of Efficacy and Safety of Modified Anti-tubercular Regimens in Treatment of Tuberculosis in Patients With Underlying Compensated and Decompensated Chronic Liver Disease
During the Study:
- Subject is required to visit every week for the first 2 months and then every month
till completion of study or as and when required
- The usual symptomatic and supportive treatment of Chronic Liver Disease, including use
of antiviral, will be given to all patients.
- Effort will be made to avoid use of other hepatotoxic drug(s) during Anti-Tubercular
Treatment.
- Liver function tests (LFT) will be done weekly during first 2 months then at one month
interval or as when required.
- The treatment efficacy of Anti-Tubercular Treatment (ATT) will be made on the basis of
clinical, biochemical, microbiological and imaging parameters at months 2, 4, 7 and 9.
Patients not improving at 4 weeks after initiation of treatment will be shifted to
alternative regimens and will be excluded from the study.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment