To Compare the Serum Apoptosis-associated Markers Between Patients With Active TB and Patients With LTBI Clinical Trial
Official title:
The Role of Apoptosis Associated Markers in Pathogenesis of Pulmonary Tuberculosis
NCT number | NCT01676155 |
Other study ID # | 20110822RC |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | August 28, 2012 |
Last updated | August 28, 2012 |
Start date | September 2011 |
To compare the serum apoptosis-associated markers between patients with active TB and patients with LTBI To evaluate the efficiency of apoptosis-associated markers to differentiate potential of active TB from LTBI
Status | Recruiting |
Enrollment | 400 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Age = 20 years - Latent TB group: family contacts who have positive response in IGRA (by QuantiFeron-TB Gold-in-Tube, which is described detail in Part C) and have no signs of active TB. - Active TB group: patients with pulmonary tuberculosis diagnosed by positive respiratory culture. Exclusion Criteria: - Age younger than 20 years. - Patients who have pregnancy. - Patients who have acquired immunodeficiency syndrome - Patients who have bleeding tendency which can not tolerate venous puncture such as hemophilia, thrombocytopenia. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | getting active tuberculosis | 2 year | No | |
Secondary | mortality | 2 years | No |