Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury

Acute Respiratory Distress Syndrome Clinical Trial

Official title:

A Phase 1 Study: The Determination of the Maximum Tolerable Dosage of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01619280
• Other study ID #: 10-0102-A
• Status: Recruiting
• Phase: Phase 1
• First received: May 29, 2012
• Last updated: June 12, 2012
• Start date: May 2012
• Est. completion date: June 2013

Study information

• Verified date: June 2012
• Source: Mount Sinai Hospital, Canada
• Contact: Terence Ip, MD
• Email: terence.ip[@]utoronto.ca
• Is FDA regulated: No
• Health authority: Canada: Health Canada
• Study type: Interventional

Clinical Trial Summary

Acute lung injury (ALI) is caused by a wide variety of conditions, but always characterized by hypoxia and non-cardiogenic pulmonary edema. Current treatment of ALI is supportive and treatment of the underlying cause. New therapies to treat severe ALI have not been shown to improve survival, and are limited by financial and logistical resources.

The investigators propose to investigate the role of inhaled sodium nitroprusside (iSNP) in ALI. Sodium nitroprusside (SNP) is a vasodilator. When inhaled, SNP may travel to areas of the lung participating in gas exchange, and cause the blood vessels surrounding these areas to enlarge. This may result in an increase of blood vessels to these areas of the lung, and improve oxygenation. Currently, iSNP has not been studied in the adult population. Therefore, this study is intended to find the safety profile of varying doses of iSNP.

Description:

Acute lung injury (ALI) is a syndrome characterized by acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. ALI is responsible for significant mortality and morbidity in the critically ill population.

Novel rescue therapies used to support oxygenation in severe ALI include inhaled nitric oxide and high frequency oscillatory ventilation; however, neither have been shown to reduce mortality and both are limited by logistical and financial challenges.

Inhaled sodium nitroprusside (iSNP) is a vasodilator which causes local vasodilation of pulmonary capillaries surrounding functional alveoli, resulting in improved oxygenation by redistributing pulmonary blood flow to areas with better ventilation-perfusion ratios. As iSNP can be administered by a low-cost nebulizer and is relatively inexpensive compared to other novel rescue therapies, this modality may be an alternative therapy for patients with severe hypoxemia. Two pediatric studies support the use of iSNP in ALI; however, iSNP has not been studied in the adult ALI population. To determine whether iSNP can improve oxygenation in adult ALI, the maximum tolerable dose (MTD) must first be determined.

Our study aims to determine the MTD of iSNP in adult ALI through an open-label, non-randomized, single centered, dose escalation study design, whereby subjects will receive iSNP for thirty minutes and have various physiologic variables recorded.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: June 2013
• Est. primary completion date: June 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Age = 18

2. Negative ß-hCG in women of child bearing age (age = 50)

3. Developed ALI within past 72 hours:

• PaO2/FiO2 < 300;

• Bilateral infiltrates on CXR;

• No clinical evidence of elevated left atrial pressure ie. Heart failure as the cause of hypoxia and bilateral infiltrates; and

• Recognized risk factor for ALI such as: pneumonia, aspiration pneumonitis, acute pancreatitis, massive blood transfusion, or sepsis

4. FiO2 = 0.5

5. PEEP = 8 cm H2O

6. Invasive arterial blood pressure line

7. Endotracheal intubation or tracheostomy

8. Conventional mechanical ventilation

9. Mean Arterial Pressure (MAP) = 65 mmHg with or without use of vasopressors (stable for at least more than 1 hour)

10. Arterial pH = 7.15

Exclusion Criteria:

1. Chest tube with active leak (eg. bronchopulmonary fistula),

2. Prone ventilation, inhaled nitric oxide, inhaled prostacyclin, high frequency oscillatory ventilation,

3. Lack of consent,

4. Untreated coarctation of aorta, symptomatic or severe/critical aortic stenosis as documented by echocardiogram or clinical history,

5. Evidence of increased intracranial pressure (eg. dilated pupils, known intracranial trauma or mass on head CT),

6. SpO2 <90%,

7. Contraindication to SNP i.e. hypersensitivity, congenital optic atrophy, tobacco amblyopia,

8. Active treatment with IV or transdermal nitroglycerin,

9. G6PD deficiency

10. CrCl < 30 ml/min or receiving renal replacement therapy, or

11. Total bilirubin > 68 µmol/L and AST or ALT level 2 times the upper limit of normal.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Lung Injury
• Acute Respiratory Distress Syndrome
• Hypoxia
• Lung Injury
• Respiratory Distress Syndrome, Adult
• Respiratory Distress Syndrome, Newborn
• Respiratory Failure
• Respiratory Insufficiency
• Sodium Nitroprusside

Intervention

Drug:
• Sodium Nitroprusside
Each subject will receive one of five possible dosages of nebulized sodium nitroprusside. The dosage will be determined by the 3 + 3 dose escalation design. Only a maximum of six patients will be given a particular dosage. Arterial blood gases will be drawn at 0 min, 15 min, 30 min and 45 min during nebulized sodium nitroprusside administration. Vitals signs will be recorded every five minutes. No changes to ventilator settings or vasopressor dosage or fluid administration will be allowed.

Locations

Country	Name	City	State
Canada	Mount Sinai Hospital, University of Toronto	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Mount Sinai Hospital, Canada

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The maximum tolerable dosage of nebulized sodium nitroprusside. This will be determined by the 3 + 3 dose finding design.	Participants will be followed for the duration of the intervention of 45 min. . It is anticipated it will take up to 1 year to recruit the required number of participants to determine the maximum tolerable dose of nebulized sodium nitroprusside.	Up to 1 year	Yes
Secondary	The change in measures of oxygenation (PaO2,SaO2,oxygenation index) during iSNP administration.		0 min, 15 min, 30 min, and 45 min	No
Secondary	The change in heart rate (HR), mean blood pressure (MAP) during iSNP administration.		0 min, 15 min, 30 min, and 45 min	Yes
Secondary	The presence or absence of lactate, and/or methemoglobin.		0 min, 15 min, 30 min, and 45 min	Yes