Parkinson`s Disease - Autonomic Dysregulation Clinical Trial
Official title:
Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease - Evolution A Monocentric Study to Investigate the Development of Symptoms of Autonomic Dysregulation in Parkinson`s Disease
Symptoms of blood pressure dysregulation, impaired swallowing and digestion are common
amongst parkinson patients. The overall aim of this study is to examine blood pressure
regulation and esophageal motility and gastric emptying in Parkinson`s disease (PD)
patients.
The investigators hypothesize that - compared to age-matched controls - PD patients display
an altered regulation of blood pressure, altered gastroesophageal motility, and delayed
gastric emptying. These symptoms occur already early in the disease process, but aggravate
with progression of the disease.
The investigators will perform a 7-day blood pressure measurement, measurement of central
blood pressure and pulse wave velocity, assessment of pulse variability, Schellong tests to
assess orthostatic function, high resolution manometry assessments during swallowing acts,
and a 13C-sodium octanoate breath test to assess gastric emptying, in 18 PD patients (9 each
Hoehn&Yahr stages 1,2) and 12 age- and gender-matched healthy controls. Results will be
interpreted in relation to the severity of PD motor symptoms.
The investigators anticipate that blood pressure dysregulation and gastroesophageal motility
disturbances will be present only in PD subjects, but not in matched controls without
neurological disorders and without any extrapyramidal motor signs. Furthermore, the
investigators expect to find an association between motor impairment and the severity of
these autonomic symptoms, however, that according to the Braak staging, subtle disturbances
must already be present in the early stages of PD.
n/a
Observational Model: Case Control, Time Perspective: Prospective