Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer. — C-ART-2

Primary Non-operated Squamous Cell Carcinoma of Hypopharynx Clinical Trial

Official title:
A Two-arm Phase II Randomized Study, Comparing Adaptive Biological Imaging - Voxel Intensity - Based Radiotherapy (Adaptive Dose Escalation) Versus Standard Radiotherapy for Head and Neck Cancer.

Status Completed

Clinical Trial Summary

The investigators hypothesize that treatment adaptation to biological and anatomical changes, occurring during treatment, can increase the chance of cure at minimized or equal radiation-induced toxicity in head and neck cancer patients. This trial compares standard intensity-modulated radiotherapy (IMRT), using only pre-treatment planning 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to adaptive 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography voxel intensity based IMRT or volumetric-modulated arc therapy (VMAT) using repetitive per-treatment planning 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography for head and neck cancer.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Carcinoma
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Primary Non-operated Squamous Cell Carcinoma of Hypopharynx
Primary Non-operated Squamous Cell Carcinoma of Larynx
Primary Non-operated Squamous Cell Carcinoma of Oral Cavity
Primary Non-operated Squamous Cell Carcinoma of Oropharynx
Squamous Cell Carcinoma of Head and Neck

Clinical Trial Details

NCT number	NCT01341535
Study type	Interventional
Source	University Hospital, Ghent
Contact
Status	Completed
Phase	Phase 2
Start date	September 2011
Completion date	July 15, 2021

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