Obesity, Insulin Sensitivity, Type 2 Diabetes Mellitus Clinical Trial
Official title:
Dietary Polyphenols as Modulators of Lipid Oxidation and Mitochondrial Function in Overweight Volunteers
There are strong indications that (combinations of) polyphenols may be attractive candidates
in the prevention of the metabolic syndrome and diabetes through modulation of pathways of
fatty acid metabolism and mitochondrial function. We hypothesize that the combination of
specific polyphenols, with partly distinct mechanisms of action, may have physiologically
significant effects on fat oxidation through additive or synergistic effects, thereby
improving body composition, insulin sensitivity and preventing type 2 diabetes. The
following objective will be addressed in the current study:
(1) to test short term (3 day) effects of combinations of polyphenols (supplements of EGCG
either in combination with resveratrol or with resveratrol and genistein) to affect systemic
lipolysis and fat oxidation during overnight fasted conditions and after ingestion of a high
fat meal in overweight subjects
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science