Ischaemia-reperfusion (IR) Injury Clinical Trial
Official title:
The Effects of C-type Natriuretic Peptide on Endothelial Function Following Ischaemia-Reperfusion in the Human Forearm
| NCT number | NCT01075776 |
| Other study ID # | 007143 |
| Secondary ID | |
| Status | Withdrawn |
| Phase | N/A |
| First received | |
| Last updated | |
| Start date | January 2020 |
| Est. completion date | January 2023 |
| Verified date | May 2020 |
| Source | Queen Mary University of London |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart
| Status | Withdrawn |
| Enrollment | 0 |
| Est. completion date | January 2023 |
| Est. primary completion date | January 2022 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years to 45 Years |
| Eligibility |
Inclusion Criteria: - Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill Exclusion Criteria: - History of medical illness - Unwillingness to sign consent form - Use of non-OCP medications - Hypertension on examination of the blood pressure |
| Country | Name | City | State |
|---|---|---|---|
| United Kingdom | Queen Mary University London | London |
| Lead Sponsor | Collaborator |
|---|---|
| Queen Mary University of London | University College, London |
United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Change in area under curve dose-response to acetylcholine after IR injury | 2h |