Tissue Sample Collection From Patients With Fanconi Anemia

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial

Official title:

Fanconi Anemia Cancer Cell Repository

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00899522
• Other study ID #: IRB00001100
• Secondary ID: P30CA069533OHSU-
• Status: Completed
• Phase: N/A
• First received: May 9, 2009
• Last updated: November 30, 2017
• Start date: August 2005
• Est. completion date: May 2013

Study information

• Verified date: November 2017
• Source: OHSU Knight Cancer Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.

Description:

OBJECTIVES:

• Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.

• Study repository tissue using a variety of molecular methods, including gene microarrays.

• Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: May 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 1 Year to 55 Years

Eligibility

DISEASE CHARACTERISTICS:

• Confirmed Fanconi anemia

• Confirmed malignant solid tumor

• Biopsy of tumor tissue available

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified

Related Conditions & MeSH terms

• Anemia
• Fanconi Anemia
• Fanconi Syndrome
• Neoplasms
• Unspecified Adult Solid Tumor, Protocol Specific
• Unspecified Childhood Solid Tumor, Protocol Specific

Intervention

Other:
• biologic sample preservation procedure
Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.

Procedure:
• biopsy
Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.

Locations

Country	Name	City	State
United States	Knight Cancer Institute at Oregon Health and Science University	Portland	Oregon

Sponsors (2)

Lead Sponsor	Collaborator
OHSU Knight Cancer Institute	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia		Duration of the study
Primary	Study tissue samples by molecular methods, including gene microarrays		Duration of the study
Primary	Development of cancer cell lines from tissue archived from patients with Fanconi anemia		Duration of the study