Infection Prophylaxis in Colo Rectal Surgery Clinical Trial
Official title:
A Prospective, Randomized, Blind, Multicenter Trial Comparing Orally Administered Trimethoprim-sulfamethoxazole With Intravenously Administered Cefuroxime and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery
The current standard Swedish infection prophylaxis in colorectal surgery is intravenously
administered cefuroxime and metronidazole. this combination is well studied. The
disadvantages of the regimen is "collateral damage" resulting from treatment with a
cephalosporine and that the combination also serves as the first line of treatment for
abdominal surgical infections.
Serval Swedish surgical departments have for some years used a combination of orally
administered trimethoprim-sulfamethoxazole and metronidazole.
The combination is economical and believed to be effective but hitherto the outcome have not
been properly researched.
The aim of this study is to compare the efficacy of these two regimens in the prevention of
infection after elective colorectal surgery.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention