Cardiomyopathy (Ischemic or Non-Ischemic) Clinical Trial
Official title:
Transcriptomal Analysis of Peripheral Blood and Skeletal Muscle in Patients Undergoing CRT Using Oligonucleotide Arrays
Genes expressing inflammatory cytokines (TNF- alpha, IL1 etc) and genes involved in
apoptosis (Caspase 3, Bax, Bcl-2, Fas) are dysregulated in the skeletal muscles of the
patients who have muscle wasting and decreased exercise capacity with CHF.
Patients who show benefit from CRT may also show reversal of the inflammatory/apoptotic
cascade that accompanies CHF and these patients may be the ones who benefit the most from
CRT
1. The general objective of this study is to:
1. To identify the molecular pathways that may be altered in the blood and skeletal
muscles of the patients undergoing CRT by using transcriptional analysis of the blood
and skeletal muscle in these patients
2. To identify objective measurable molecular signals, using gene expression profiling,
that correlate with clinical improvement in patients undergoing CRT.
3. To identify the molecular profile of patients who are most likely to benefit from CRT
with improvement of exercise capacity and reversal of cardiac cachexia.
4. To identify biochemical pathways involved in cardiac cachexia.
5. To identify genes involved in positive remodeling and reversal of apoptotic cascade in
the skeletal muscle.
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Observational Model: Cohort, Time Perspective: Prospective