Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia

Recurrent Childhood Acute Lymphoblastic Leukemia Clinical Trial

Official title:

A Phase II Study of Rituximab (IND #7028) and Ifosfamide, Carboplatin and Etoposide (ICE) Chemotherapy in Children With Recurrent/Refractory B-cell (CD20+) Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00058461
• Other study ID #: NCI-2012-01804
• Secondary ID: NCI-2012-01804CO
• Status: Terminated
• Phase: Phase 2
• First received: April 7, 2003
• Last updated: October 7, 2013
• Start date: November 2003

Study information

• Verified date: October 2013
• Source: National Cancer Institute (NCI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This phase II trial is studying how well rituximab together with ifosfamide, carboplatin, and etoposide works in treating young patients with recurrent or refractory non-Hodgkin's lymphoma or acute lymphoblastic leukemia. Chemotherapy drugs, such as ifosfamide, carboplatin, and etoposide, work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining ifosfamide, carboplatin, and etoposide with rituximab may kill more cancer cells.

Description:

PRIMARY OBJECTIVES:

I. Determine the response of pediatric patients with relapsed or refractory B-cell non-Hodgkin's lymphoma or acute lymphoblastic leukemia treated with ifosfamide, carboplatin, and etoposide combined with rituximab.

II. Determine the relapse-free survival rate of patients treated with this regimen.

III. Determine the toxicity profile of this regimen in these patients, specifically the frequency of therapy delays between courses due to prolonged grade IV hematologic toxicity.

SECONDARY OBJECTIVES:

I. Determine whether this regimen plus filgrastim (G-CSF) will result in mobilization of greater than 2 X 10^6/kg peripheral blood stem cells (CD34+ cells, PBSC) in at least 80% of patients for whom peripheral stem cell collection is performed.

II. Determine the time course of engraftment for patients who undergo peripheral stem cell transplantation after collection of stem cells using this mobilization regimen.

OUTLINE: This is a multicenter study. Patients are stratified by disease (B-cell large cell lymphoma or atypical precursor B-cell lymphoblastic lymphoma vs small non-cleaved cell lymphoma or B-cell acute lymphoblastic leukemia).

Patients receive ifosfamide IV over 2 hours and etoposide IV over 1 hour on days 3-5, rituximab IV on days 1 and 3, and carboplatin IV over 1 hour on day 3. Patients receive filgrastim (G-CSF) subcutaneously once daily beginning on day 6 and continuing until blood counts recover. Patients also receive intrathecal (IT) chemotherapy comprising methotrexate and cytarabine. Patients with B-cell large cell lymphoma and negative CSF cytology receive IT chemotherapy on day 3 of the first course only. Patients with small non-cleaved cell lymphoma or B-cell acute lymphoblastic leukemia and negative CSF cytology receive IT chemotherapy on day 3. All patients with positive CSF cytology receive IT chemotherapy on days 3, 10, and 17 of the first and second courses. Treatment repeats every 23 days for up to 3 courses in the absence of disease progression or unacceptable toxicity.

Patients are followed for survival.

PROJECTED ACCRUAL: A total of 42-82 patients (21-41 per disease stratum) will be accrued for this study within 2-4 years.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 82
• Est. primary completion date: March 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 21 Years

Eligibility

Inclusion Criteria:

• Histologically confirmed B-cell non-Hodgkin's lymphoma OR acute lymphoblastic leukemia

• CD20+ (confirmed by flow cytometry of tumor tissue, involved marrow, or CD20 immunostaining)

• The following histologies are generally CD20+ and are eligible:

• Diffuse large B-cell lymphoma, mediastinal (thymic) large B-cell lymphoma, or follicular lymphoma, grade III (rare), documented by flow cytometry or appropriate immunohistochemistry, any stage

• Burkitt's lymphoma or atypical Burkitt's/Burkitt-like lymphoma, any stage

• B-cell acute lymphoblastic leukemia, with FABL3 morphology and/or demonstration of surface immunoglobin by flow cytometry

• Atypical precursor B-cell lymphoblastic lymphoma or other unusual histologies that are CD20+

• Measurable disease by clinical, radiographic, or histologic criteria

• Must be in first or later recurrence or have disease that is primarily refractory to conventional therapy

• No isolated CNS disease

• Performance status - ECOG 0-2

• At least 2 months

• Absolute neutrophil count = 1,000/mm^3*

• Platelet count = 100,000/mm^3 (transfusion independent)*

• Hemoglobin = 10.0 g/dL (RBC transfusion allowed)*

• Bilirubin = 1.5 times normal

• ALT < 2.5 times normal

• No chronic renal insufficiency

• Renal insufficiency allowed provided it is secondary to tumor lysis syndrome

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 3 months after study treatment

• HIV negative

• No active uncontrolled infection

• Seizure disorder allowed if well controlled with anticonvulsants

• No CNS toxicity greater than grade II

• At least 24 hours since prior growth factor(s)

• At least 60 days since prior biologic (antineoplastic) therapy

• Prior stem cell transplantation allowed provided the following criteria are met:

• More than 60 days since transplantation

• Hematopoietic lab value requirements are met (See Hematopoietic)

• No evidence of graft-versus-host disease (if post-allogeneic transplantation)

• Prior monoclonal antibody therapy allowed (including rituximab)

• No other concurrent immunomodulating agents

• More than 2 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas)

• No other concurrent chemotherapy

• No concurrent steroids (except for rituximab infusion-related symptoms)

• At least 2 weeks since prior local palliative radiotherapy (small port)

• At least 6 weeks since prior substantial bone marrow radiotherapy

• At least 6 months since prior craniospinal radiotherapy or radiotherapy to 50% or more of the pelvis

• Concurrent radiotherapy to localized painful, airway-compromising, or other acute organ-threatening lesions allowed provided at least 1 measurable lesion is not irradiated

• Recovered from prior therapy

• No concurrent participation in another phase II study

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• B-cell Childhood Acute Lymphoblastic Leukemia
• Burkitt Lymphoma
• Childhood Burkitt Lymphoma
• Childhood Diffuse Large Cell Lymphoma
• Childhood Immunoblastic Large Cell Lymphoma
• L3 Childhood Acute Lymphoblastic Leukemia
• Leukemia
• Leukemia, Lymphoid
• Lymphoma
• Lymphoma, Large B-Cell, Diffuse
• Lymphoma, Large-Cell, Immunoblastic
• Lymphoma, Non-Hodgkin
• Precursor Cell Lymphoblastic Leukemia-Lymphoma
• Recurrent Childhood Acute Lymphoblastic Leukemia
• Recurrent Childhood Large Cell Lymphoma
• Recurrent Childhood Lymphoblastic Lymphoma
• Recurrent Childhood Small Noncleaved Cell Lymphoma

Intervention

Drug:
• ifosfamide
Given IV
• etoposide
Given IV

Biological:
• rituximab
Given IV

Drug:
• carboplatin
Given IV

Biological:
• filgrastim
Given SC

Drug:
• methotrexate
Given IT
• cytarabine
Given IT

Other:
• laboratory biomarker analysis
Correlative studies

Locations

Country	Name	City	State
United States	Children's Oncology Group	Arcadia	California

Sponsors (1)

Lead Sponsor	Collaborator
National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Response rate determined by physical exam and appropriate imaging studies	Response rates and confidence intervals will be constructed according to the method of Chang and O'Brien.	Up to 3 years	No
Primary	Relapse-free survival rate	Estimated by the Kaplan-Meier method.	Up to 3 years	No
Primary	Toxicity as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE)		Up to 3 years	Yes
Secondary	CD34 cells mobilization by flow cytometry		At the completion of 2 courses of treatment	No