Pulmonary Disease, Chronic Obstructive Clinical Trial
To determine if ABX-IL8 will improve shortness of breath.
Chronic Obstructive Pulmonary Disease (COPD) is defined as a disease state characterized by
the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow
obstruction is generally progressive, may be accompanied by airway hyper-reactivity, and may
be partially reversible. Inflammation in the lungs is triggered by exposure to inhaled toxic
substances that can lead to tissue damage, mucous secretion, airways narrowing and tissue
destruction.
Interleukin-8 (IL-8) plays a major role in elevating sputum in patients with COPD and may
contribute to tissue destruction. Therefore, the highly specific antibody to IL-8 (such as
ABX-IL8) may help to reduce mucous production and tissue destruction.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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