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Clinical Trial Summary

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled, 2-period, 2-treatment cross-over study to evaluate the efficacy and safety of orally administered deucrictibant compared to placebo for the on-demand treatment of HAE attacks, including non-severe laryngeal attacks, in participants ≥12 to ≤75 years of age with HAE type 1 or type 2 (HAE-1/2), a proportion of whom are using long-term prophylactic medication for HAE.


Clinical Trial Description

The study consists of a Screening Phase during which eligibility is confirmed, a Treatment Phase in which participants will be randomized and receive double blinded study drug to treat 2 qualifying HAE attacks (i.e., 2 Treatment Periods within the Treatment Phase), and an End-of-Study Follow-up Phase after the second attack treated with study drug. In addition, for adolescent participants (age ≥12 to <18 years), PK samples are collected after administration of deucrictibant at Day 1 in a non-attack state. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06343779
Study type Interventional
Source Pharvaris Netherlands B.V.
Contact Pharvaris Clinical Team
Phone +31 (71) 203-6410
Email clinicaltrials@pharvaris.com
Status Recruiting
Phase Phase 3
Start date February 26, 2024
Completion date March 2026

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