Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome

Proton Pump Inhibitor Adverse Reaction Clinical Trial

Official title: Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome: A Cross-Sectional Case-Control Study

Status Completed

Clinical Trial Summary

Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.

Clinical Trial Description

The study included a total of 75 participants, with 45 individuals classified as long-term PPI users and 30 as non-PPI users. The PPI user group was defined as those who had been consistently using PPIs (specifically omeprazole, lansoprazole, pantoprazole, esomeprazole, or rabeprazole) on a daily basis for a minimum of 6 months or at least twice a week for a minimum of 2 years. The control group comprised individuals who had never used PPIs. Venous blood samples were taken from all participants to measure serum zonulin levels. ;

Related Conditions & MeSH terms

• Proton Pump Inhibitor Adverse Reaction

• NCT number: NCT06268834
• Study type: Interventional
• Source: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
• Status: Completed
• Phase: N/A
• Start date: October 4, 2023
• Completion date: December 31, 2023